Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models

Glioblastoma multiforme (GBM) is the most aggressive primary tumor of the central nervous system and the diagnosis is often dismal. GBM pharmacological treatment is strongly limited by its intracranial location beyond the blood–brain barrier (BBB). While Temozolomide (TMZ) exhibits the best clinical...

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Detalles Bibliográficos
Autores principales: Gherardini, Lisa, Vetri Buratti, Veronica, Maturi, Mirko, Inzalaco, Giovanni, Locatelli, Erica, Sambri, Letizia, Gargiulo, Sara, Barone, Virginia, Bonente, Denise, Bertelli, Eugenio, Tortorella, Silvia, Franci, Lorenzo, Fioravanti, Antonio, Comes Franchini, Mauro, Chiariello, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030813/
https://www.ncbi.nlm.nih.gov/pubmed/36944737
http://dx.doi.org/10.1038/s41598-023-31811-5

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