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Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice
As a central part of the mammalian brain, the prefrontal cortex (PFC) has been implicated in regulating cocaine-induced behaviors including compulsive seeking and reinstatement. Although dysfunction of the PFC has been reported in animal and human users with chronic cocaine abuse, less is known abou...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030897/ https://www.ncbi.nlm.nih.gov/pubmed/36944634 http://dx.doi.org/10.1038/s41467-023-37045-3 |
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author | Wang, Lun Gao, Min Wang, Qinglong Sun, Liyuan Younus, Muhammad Ma, Sixing Liu, Can Shi, Li Lu, Yang Zhou, Bo Sun, Suhua Chen, Guoqing Li, Jie Zhang, Quanfeng Zhu, Feipeng Wang, Changhe Zhou, Zhuan |
author_facet | Wang, Lun Gao, Min Wang, Qinglong Sun, Liyuan Younus, Muhammad Ma, Sixing Liu, Can Shi, Li Lu, Yang Zhou, Bo Sun, Suhua Chen, Guoqing Li, Jie Zhang, Quanfeng Zhu, Feipeng Wang, Changhe Zhou, Zhuan |
author_sort | Wang, Lun |
collection | PubMed |
description | As a central part of the mammalian brain, the prefrontal cortex (PFC) has been implicated in regulating cocaine-induced behaviors including compulsive seeking and reinstatement. Although dysfunction of the PFC has been reported in animal and human users with chronic cocaine abuse, less is known about how the PFC is involved in cocaine-induced behaviors. By using two-photon Ca(2+) imaging to simultaneously record tens of intact individual networking neurons in the frontal association cortex (FrA) in awake male mice, here we report that a systematic acute cocaine exposure decreased the FrA neural activity in mice, while the chemogenetic intervention blocked the cocaine-induced locomotor sensitization. The hypoactivity of FrA neurons was critically dependent on both dopamine transporters and dopamine transmission in the ventromedial PFC (vmPFC). Both dopamine D1R and D2R neurons in the vmPFC projected to and innervated FrA neurons, the manipulation of which changed the cocaine-induced hypoactivity of the FrA and locomotor sensitization. Together, this work demonstrates acute cocaine-induced hypoactivity of FrA neurons in awake mice, which defines a cortico-cortical projection bridging dopamine transmission and cocaine sensitization. |
format | Online Article Text |
id | pubmed-10030897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100308972023-03-23 Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice Wang, Lun Gao, Min Wang, Qinglong Sun, Liyuan Younus, Muhammad Ma, Sixing Liu, Can Shi, Li Lu, Yang Zhou, Bo Sun, Suhua Chen, Guoqing Li, Jie Zhang, Quanfeng Zhu, Feipeng Wang, Changhe Zhou, Zhuan Nat Commun Article As a central part of the mammalian brain, the prefrontal cortex (PFC) has been implicated in regulating cocaine-induced behaviors including compulsive seeking and reinstatement. Although dysfunction of the PFC has been reported in animal and human users with chronic cocaine abuse, less is known about how the PFC is involved in cocaine-induced behaviors. By using two-photon Ca(2+) imaging to simultaneously record tens of intact individual networking neurons in the frontal association cortex (FrA) in awake male mice, here we report that a systematic acute cocaine exposure decreased the FrA neural activity in mice, while the chemogenetic intervention blocked the cocaine-induced locomotor sensitization. The hypoactivity of FrA neurons was critically dependent on both dopamine transporters and dopamine transmission in the ventromedial PFC (vmPFC). Both dopamine D1R and D2R neurons in the vmPFC projected to and innervated FrA neurons, the manipulation of which changed the cocaine-induced hypoactivity of the FrA and locomotor sensitization. Together, this work demonstrates acute cocaine-induced hypoactivity of FrA neurons in awake mice, which defines a cortico-cortical projection bridging dopamine transmission and cocaine sensitization. Nature Publishing Group UK 2023-03-21 /pmc/articles/PMC10030897/ /pubmed/36944634 http://dx.doi.org/10.1038/s41467-023-37045-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wang, Lun Gao, Min Wang, Qinglong Sun, Liyuan Younus, Muhammad Ma, Sixing Liu, Can Shi, Li Lu, Yang Zhou, Bo Sun, Suhua Chen, Guoqing Li, Jie Zhang, Quanfeng Zhu, Feipeng Wang, Changhe Zhou, Zhuan Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice |
title | Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice |
title_full | Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice |
title_fullStr | Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice |
title_full_unstemmed | Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice |
title_short | Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice |
title_sort | cocaine induces locomotor sensitization through a dopamine-dependent vta-mpfc-fra cortico-cortical pathway in male mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030897/ https://www.ncbi.nlm.nih.gov/pubmed/36944634 http://dx.doi.org/10.1038/s41467-023-37045-3 |
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