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Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years
The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030936/ https://www.ncbi.nlm.nih.gov/pubmed/36969600 http://dx.doi.org/10.3389/fphys.2023.1102526 |
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author | Jemni, Monèm Zaman, Rashid Carrick, Frederick Robert Clarke, Neil David Marina, Michel Bottoms, Lindsay Matharoo, Jagdeep Singh Ramsbottom, Roger Hoffman, Norman Groves, Shad James Gu, Yaodong Konukman, Ferman |
author_facet | Jemni, Monèm Zaman, Rashid Carrick, Frederick Robert Clarke, Neil David Marina, Michel Bottoms, Lindsay Matharoo, Jagdeep Singh Ramsbottom, Roger Hoffman, Norman Groves, Shad James Gu, Yaodong Konukman, Ferman |
author_sort | Jemni, Monèm |
collection | PubMed |
description | The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise. |
format | Online Article Text |
id | pubmed-10030936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100309362023-03-23 Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years Jemni, Monèm Zaman, Rashid Carrick, Frederick Robert Clarke, Neil David Marina, Michel Bottoms, Lindsay Matharoo, Jagdeep Singh Ramsbottom, Roger Hoffman, Norman Groves, Shad James Gu, Yaodong Konukman, Ferman Front Physiol Physiology The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10030936/ /pubmed/36969600 http://dx.doi.org/10.3389/fphys.2023.1102526 Text en Copyright © 2023 Jemni, Zaman, Carrick, Clarke, Marina, Bottoms, Matharoo, Ramsbottom, Hoffman, Groves, Gu and Konukman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Jemni, Monèm Zaman, Rashid Carrick, Frederick Robert Clarke, Neil David Marina, Michel Bottoms, Lindsay Matharoo, Jagdeep Singh Ramsbottom, Roger Hoffman, Norman Groves, Shad James Gu, Yaodong Konukman, Ferman Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years |
title | Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years |
title_full | Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years |
title_fullStr | Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years |
title_full_unstemmed | Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years |
title_short | Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years |
title_sort | exercise improves depression through positive modulation of brain-derived neurotrophic factor (bdnf). a review based on 100 manuscripts over 20 years |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030936/ https://www.ncbi.nlm.nih.gov/pubmed/36969600 http://dx.doi.org/10.3389/fphys.2023.1102526 |
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