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The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer
Endometrial cancer is the most common gynecologic malignancy in the developed world. Risk stratification and treatment approaches are changing due to better understanding of tumor biology. Upregulated Wnt signaling plays an important role in cancer initiation and progression with promising potential...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031053/ https://www.ncbi.nlm.nih.gov/pubmed/36969079 http://dx.doi.org/10.3389/fonc.2023.1013463 |
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author | Ledinek, Živa Sobočan, Monika Sisinger, Damjan Hojnik, Marko Büdefeld, Tomaž Potočnik, Uroš Knez, Jure |
author_facet | Ledinek, Živa Sobočan, Monika Sisinger, Damjan Hojnik, Marko Büdefeld, Tomaž Potočnik, Uroš Knez, Jure |
author_sort | Ledinek, Živa |
collection | PubMed |
description | Endometrial cancer is the most common gynecologic malignancy in the developed world. Risk stratification and treatment approaches are changing due to better understanding of tumor biology. Upregulated Wnt signaling plays an important role in cancer initiation and progression with promising potential for development of specific Wnt inhibitor therapy. One of the ways in which Wnt signaling contributes to progression of cancer, is by activating epithelial-to-mesenchymal transition (EMT) in tumor cells, causing the expression of mesenchymal markers, and enabling tumor cells to dissociate and migrate. This study analyzed the expression of Wnt signaling and EMT markers in endometrial cancer. Wnt signaling and EMT markers were significantly correlated with hormone receptors status in EC, but not with other clinico-pathological characteristics. Expression of Wnt antagonist, Dkk1 was significantly different between the ESGO-ESTRO-ESP patient risk assessment categories using integrated molecular risk assessment. |
format | Online Article Text |
id | pubmed-10031053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100310532023-03-23 The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer Ledinek, Živa Sobočan, Monika Sisinger, Damjan Hojnik, Marko Büdefeld, Tomaž Potočnik, Uroš Knez, Jure Front Oncol Oncology Endometrial cancer is the most common gynecologic malignancy in the developed world. Risk stratification and treatment approaches are changing due to better understanding of tumor biology. Upregulated Wnt signaling plays an important role in cancer initiation and progression with promising potential for development of specific Wnt inhibitor therapy. One of the ways in which Wnt signaling contributes to progression of cancer, is by activating epithelial-to-mesenchymal transition (EMT) in tumor cells, causing the expression of mesenchymal markers, and enabling tumor cells to dissociate and migrate. This study analyzed the expression of Wnt signaling and EMT markers in endometrial cancer. Wnt signaling and EMT markers were significantly correlated with hormone receptors status in EC, but not with other clinico-pathological characteristics. Expression of Wnt antagonist, Dkk1 was significantly different between the ESGO-ESTRO-ESP patient risk assessment categories using integrated molecular risk assessment. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10031053/ /pubmed/36969079 http://dx.doi.org/10.3389/fonc.2023.1013463 Text en Copyright © 2023 Ledinek, Sobočan, Sisinger, Hojnik, Büdefeld, Potočnik and Knez https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Ledinek, Živa Sobočan, Monika Sisinger, Damjan Hojnik, Marko Büdefeld, Tomaž Potočnik, Uroš Knez, Jure The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer |
title | The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer |
title_full | The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer |
title_fullStr | The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer |
title_full_unstemmed | The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer |
title_short | The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer |
title_sort | association of wnt-signalling and emt markers with clinical characteristics in women with endometrial cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031053/ https://www.ncbi.nlm.nih.gov/pubmed/36969079 http://dx.doi.org/10.3389/fonc.2023.1013463 |
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