Cargando…
Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study
INTRODUCTION: Thyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on the occurrence of thyroid autoimmunity after COVID-19 resolution. We assessed the prevalence of autoimmune th...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031076/ https://www.ncbi.nlm.nih.gov/pubmed/36967795 http://dx.doi.org/10.3389/fendo.2023.1126683 |
_version_ | 1784910523494563840 |
---|---|
author | Rossini, Alessandro Cassibba, Sara Perticone, Francesca Benatti, Simone Vasilij Venturelli, Serena Carioli, Greta Ghirardi, Arianna Rizzi, Marco Barbui, Tiziano Trevisan, Roberto Ippolito, Silvia |
author_facet | Rossini, Alessandro Cassibba, Sara Perticone, Francesca Benatti, Simone Vasilij Venturelli, Serena Carioli, Greta Ghirardi, Arianna Rizzi, Marco Barbui, Tiziano Trevisan, Roberto Ippolito, Silvia |
author_sort | Rossini, Alessandro |
collection | PubMed |
description | INTRODUCTION: Thyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on the occurrence of thyroid autoimmunity after COVID-19 resolution. We assessed the prevalence of autoimmune thyroid disease (ATD) and thyroid dysfunctions in COVID-19 survivors three months after hospital admission. DESIGN AND METHODS: Single-center, prospective, observational, cohort study performed at ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. 599 COVID-19 survivors were prospectively evaluated for thyroid function and autoimmunity thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb). When a positive antibody concentration was detected, thyroid ultrasound was performed. Multiple logistic regression model was used to estimate the association between autoimmunity and demographic characteristics, respiratory support, and comorbidities. Autoimmunity results were compared to a cohort of 498 controls referred to our Institution for non-thyroid diseases before the pandemic onset. A sensitivity analysis comparing 330 COVID-19 patients with 330 age and sex-matched controls was performed. RESULTS: Univariate and multivariate analysis found that female sex was positively associated (OR 2.01, SE 0.48, p = 0.003), and type 2 diabetes (T2DM) was negatively associated (OR 0.36, SE 0.16, p = 0.025) with thyroid autoimmunity; hospitalization, ICU admission, respiratory support, or COVID-19 treatment were not associated with thyroid autoimmunity (p > 0.05). TPOAb prevalence was greater in COVID-19 survivors than in controls: 15.7% vs 7.7%, p = 0.002. Ultrasonographic features of thyroiditis were present in 94.9% of the evaluated patients with positive antibodies. TSH was within the normal range in 95% of patients. CONCLUSIONS: Autoimmune thyroid disease prevalence in COVID-19 survivors was doubled as compared to age and sex-matched controls, suggesting a role of SARS-CoV-2 in eliciting thyroid autoimmunity. |
format | Online Article Text |
id | pubmed-10031076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100310762023-03-23 Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study Rossini, Alessandro Cassibba, Sara Perticone, Francesca Benatti, Simone Vasilij Venturelli, Serena Carioli, Greta Ghirardi, Arianna Rizzi, Marco Barbui, Tiziano Trevisan, Roberto Ippolito, Silvia Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Thyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on the occurrence of thyroid autoimmunity after COVID-19 resolution. We assessed the prevalence of autoimmune thyroid disease (ATD) and thyroid dysfunctions in COVID-19 survivors three months after hospital admission. DESIGN AND METHODS: Single-center, prospective, observational, cohort study performed at ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. 599 COVID-19 survivors were prospectively evaluated for thyroid function and autoimmunity thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb). When a positive antibody concentration was detected, thyroid ultrasound was performed. Multiple logistic regression model was used to estimate the association between autoimmunity and demographic characteristics, respiratory support, and comorbidities. Autoimmunity results were compared to a cohort of 498 controls referred to our Institution for non-thyroid diseases before the pandemic onset. A sensitivity analysis comparing 330 COVID-19 patients with 330 age and sex-matched controls was performed. RESULTS: Univariate and multivariate analysis found that female sex was positively associated (OR 2.01, SE 0.48, p = 0.003), and type 2 diabetes (T2DM) was negatively associated (OR 0.36, SE 0.16, p = 0.025) with thyroid autoimmunity; hospitalization, ICU admission, respiratory support, or COVID-19 treatment were not associated with thyroid autoimmunity (p > 0.05). TPOAb prevalence was greater in COVID-19 survivors than in controls: 15.7% vs 7.7%, p = 0.002. Ultrasonographic features of thyroiditis were present in 94.9% of the evaluated patients with positive antibodies. TSH was within the normal range in 95% of patients. CONCLUSIONS: Autoimmune thyroid disease prevalence in COVID-19 survivors was doubled as compared to age and sex-matched controls, suggesting a role of SARS-CoV-2 in eliciting thyroid autoimmunity. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10031076/ /pubmed/36967795 http://dx.doi.org/10.3389/fendo.2023.1126683 Text en Copyright © 2023 Rossini, Cassibba, Perticone, Benatti, Venturelli, Carioli, Ghirardi, Rizzi, Barbui, Trevisan and Ippolito https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Rossini, Alessandro Cassibba, Sara Perticone, Francesca Benatti, Simone Vasilij Venturelli, Serena Carioli, Greta Ghirardi, Arianna Rizzi, Marco Barbui, Tiziano Trevisan, Roberto Ippolito, Silvia Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study |
title | Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study |
title_full | Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study |
title_fullStr | Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study |
title_full_unstemmed | Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study |
title_short | Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study |
title_sort | increased prevalence of autoimmune thyroid disease after covid-19: a single-center, prospective study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031076/ https://www.ncbi.nlm.nih.gov/pubmed/36967795 http://dx.doi.org/10.3389/fendo.2023.1126683 |
work_keys_str_mv | AT rossinialessandro increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT cassibbasara increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT perticonefrancesca increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT benattisimonevasilij increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT venturelliserena increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT carioligreta increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT ghirardiarianna increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT rizzimarco increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT barbuitiziano increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT trevisanroberto increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy AT ippolitosilvia increasedprevalenceofautoimmunethyroiddiseaseaftercovid19asinglecenterprospectivestudy |