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Mathematical modeling and biochemical analysis support partially ordered calmodulin-myosin light chain kinase binding

Activation of myosin light chain kinase (MLCK) by calcium ions (Ca(2+)) and calmodulin (CaM) plays an important role in numerous cellular functions including vascular smooth muscle contraction and cellular motility. Despite extensive biochemical analysis, aspects of the mechanism of activation remai...

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Detalles Bibliográficos
Autores principales:	MacEwen, Melissa J.S., Rusnac, Domnita-Valeria, Ermias, Henok, Locke, Timothy M., Gizinski, Hayden E., Dexter, Joseph P., Sancak, Yasemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031086/ https://www.ncbi.nlm.nih.gov/pubmed/36968084 http://dx.doi.org/10.1016/j.isci.2023.106146

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