Design, synthesis and evaluation of a series of potential prodrugs of a Bruton’s tyrosine kinase (BTK) inhibitor

BTK has become a particularly attractive therapeutic target in autoimmune diseases and B-cell malignancies, making BTK inhibitors a valuable and important therapeutic option. We present the design, synthesis, and evaluation of a series of prodrugs of a BTK inhibitor with an insoluble 2,5-diaminopyri...

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Detalles Bibliográficos
Autores principales: Xiao, Zhou-Peng, Liao, Min, Huang, Xue-Juan, Wang, Yu-Tong, Lan, Xiao-Cui, Wang, Xue-Ying, Li, Xi-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031131/
https://www.ncbi.nlm.nih.gov/pubmed/36969836
http://dx.doi.org/10.3389/fphar.2023.1162216

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