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The yeast ALA synthase C‐terminus positively controls enzyme structure and function

5‐Aminolevulinic acid synthase (ALAS) is a pyridoxal 5′‐phosphate (PLP)‐dependent enzyme that catalyzes the first and rate‐limiting step of heme biosynthesis in α‐proteobacteria and several non‐plant eukaryotes. All ALAS homologs contain a highly conserved catalytic core, but eukaryotes also have a...

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Detalles Bibliográficos
Autores principales: Tran, Jenny U., Brown, Breann L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031213/
https://www.ncbi.nlm.nih.gov/pubmed/36807942
http://dx.doi.org/10.1002/pro.4600