Cargando…

Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease

Acoustic myography (AMG) noninvasively probes muscle activity. We explored whether AMG captures abnormal motor activity in patients with Parkinson's disease (PD) and how this activity is modulated by antiparkinsonian medication. Twenty patients with PD underwent AMG of the biceps, triceps, exte...

Descripción completa

Detalles Bibliográficos
Autores principales: Celicanin, M., Harrison, A. P., Kvistgaard Olsen, J., Korbo, L., Løkkegård, A., Danneskiold‐Samsøe, B., Siebner, H. R., Ilic, T. V., Bartels, E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031214/
https://www.ncbi.nlm.nih.gov/pubmed/36945885
http://dx.doi.org/10.14814/phy2.15631
_version_ 1784910555699478528
author Celicanin, M.
Harrison, A. P.
Kvistgaard Olsen, J.
Korbo, L.
Løkkegård, A.
Danneskiold‐Samsøe, B.
Siebner, H. R.
Ilic, T. V.
Bartels, E. M.
author_facet Celicanin, M.
Harrison, A. P.
Kvistgaard Olsen, J.
Korbo, L.
Løkkegård, A.
Danneskiold‐Samsøe, B.
Siebner, H. R.
Ilic, T. V.
Bartels, E. M.
author_sort Celicanin, M.
collection PubMed
description Acoustic myography (AMG) noninvasively probes muscle activity. We explored whether AMG captures abnormal motor activity in patients with Parkinson's disease (PD) and how this activity is modulated by antiparkinsonian medication. Twenty patients with PD underwent AMG of the biceps, triceps, extensor carpi radialis longus, and adductor policis muscles of the more affected arm during active and passive movements, using a mobile AMG device (CURO, Denmark). AMG and assessment of motor symptoms were performed in a pragmatic off‐medication state, as well as one and 3 h after oral intake of 200 mg levodopa. Three AMG parameters were calculated using the CURO analysis system. Motor efficiency was expressed by the E‐score, muscle fiber recruitment by the temporal T‐score, spatial summation by the S‐score, and S/T ratio. Twenty age‐ and sex‐matched healthy subjects served as controls. Group mean values were statistically compared using unpaired two‐tailed adjusted t‐test and ANOVA with Tukey´s correction for multiple comparison (p ≤ 0.05). For the biceps and extensor carpi radialis longus muscles, the active movement S:T ratio was lower in PD relative to healthy controls. The E‐score was also lower during active and passive flexion/extension movements in the off‐medication state. No significant between‐group differences in the AMG scores were noted for the triceps muscle during active or passive movements. The active S:T ratio and the E‐score during active elbow flexion and extension may offer a useful means to quickly assess abnormal motor activity and the effect of drug treatment in PD.
format Online
Article
Text
id pubmed-10031214
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-100312142023-03-23 Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease Celicanin, M. Harrison, A. P. Kvistgaard Olsen, J. Korbo, L. Løkkegård, A. Danneskiold‐Samsøe, B. Siebner, H. R. Ilic, T. V. Bartels, E. M. Physiol Rep Original Articles Acoustic myography (AMG) noninvasively probes muscle activity. We explored whether AMG captures abnormal motor activity in patients with Parkinson's disease (PD) and how this activity is modulated by antiparkinsonian medication. Twenty patients with PD underwent AMG of the biceps, triceps, extensor carpi radialis longus, and adductor policis muscles of the more affected arm during active and passive movements, using a mobile AMG device (CURO, Denmark). AMG and assessment of motor symptoms were performed in a pragmatic off‐medication state, as well as one and 3 h after oral intake of 200 mg levodopa. Three AMG parameters were calculated using the CURO analysis system. Motor efficiency was expressed by the E‐score, muscle fiber recruitment by the temporal T‐score, spatial summation by the S‐score, and S/T ratio. Twenty age‐ and sex‐matched healthy subjects served as controls. Group mean values were statistically compared using unpaired two‐tailed adjusted t‐test and ANOVA with Tukey´s correction for multiple comparison (p ≤ 0.05). For the biceps and extensor carpi radialis longus muscles, the active movement S:T ratio was lower in PD relative to healthy controls. The E‐score was also lower during active and passive flexion/extension movements in the off‐medication state. No significant between‐group differences in the AMG scores were noted for the triceps muscle during active or passive movements. The active S:T ratio and the E‐score during active elbow flexion and extension may offer a useful means to quickly assess abnormal motor activity and the effect of drug treatment in PD. John Wiley and Sons Inc. 2023-03-22 /pmc/articles/PMC10031214/ /pubmed/36945885 http://dx.doi.org/10.14814/phy2.15631 Text en © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Celicanin, M.
Harrison, A. P.
Kvistgaard Olsen, J.
Korbo, L.
Løkkegård, A.
Danneskiold‐Samsøe, B.
Siebner, H. R.
Ilic, T. V.
Bartels, E. M.
Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
title Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
title_full Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
title_fullStr Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
title_full_unstemmed Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
title_short Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
title_sort probing motor dynamics at the muscle level—acoustic myography in parkinson's disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031214/
https://www.ncbi.nlm.nih.gov/pubmed/36945885
http://dx.doi.org/10.14814/phy2.15631
work_keys_str_mv AT celicaninm probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT harrisonap probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT kvistgaardolsenj probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT korbol probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT løkkegarda probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT danneskioldsamsøeb probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT siebnerhr probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT ilictv probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease
AT bartelsem probingmotordynamicsatthemusclelevelacousticmyographyinparkinsonsdisease