Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis

Dihydrofolate reductase (DHFR), a housekeeping enzyme in primary metabolism, has been extensively studied as a model of acid-base catalysis and a clinic drug target. Herein, we investigated the enzymology of a DHFR-like protein SacH in safracin (SAC) biosynthesis, which reductively inactivates hemia...

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Detalles Bibliográficos
Autores principales: Shao, Ning, Ma, Xueyang, Zhang, Ying-Ying, Yang, Donghui, Ma, Ming, Tang, Gong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031226/
https://www.ncbi.nlm.nih.gov/pubmed/36970210
http://dx.doi.org/10.1016/j.apsb.2022.10.005

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