Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...

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Detalles Bibliográficos
Autores principales: Zhou, Qian, Le, Meiling, Yang, Yiyi, Wang, Wenjuan, Huang, Yuqi, Wang, Quan, Tian, Yijing, Jiang, Meiyan, Rao, Yong, Luo, Hai-Bin, Wu, Yinuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031254/
https://www.ncbi.nlm.nih.gov/pubmed/36970192
http://dx.doi.org/10.1016/j.apsb.2022.09.023

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