BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer’s patients’ iPSCs in senescence-related conditions

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In addition to increasing β-amyloid plaque deposition and tau tangle formation, inhibition of neurogenesis has recently been observed in Alzheimer’s disease (AD). This study generated a cellular model that recapitulated neurogenesis defects observed in patients with AD, using induced pluripotent ste...

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Detalles Bibliográficos
Autores principales: Nakatsu, Daiki, Kunishige, Rina, Taguchi, Yuki, Shinozaki-Narikawa, Naeko, Osaka, Kishiko, Yokomizo, Kayo, Ishida, Mami, Takei, Shunsuke, Yamasaki, Shoko, Hagiya, Keita, Hattori, Kotaro, Tsukamoto, Tadashi, Murata, Masayuki, Kano, Fumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031282/
https://www.ncbi.nlm.nih.gov/pubmed/36764297
http://dx.doi.org/10.1016/j.stemcr.2023.01.004
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