CFTR High Expresser Cells in cystic fibrosis and intestinal diseases

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl(−)/HCO(3)(−) channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many gastrointestinal diseases. Defects in CFTR lead to intestinal dysfunction, malabsorption, obstruction, infection, inflammation, and cancer...

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Detalles Bibliográficos
Autores principales: Carlos dos Reis, Diego, Dastoor, Parinaz, Santos, Anderson Kenedy, Sumigray, Kaelyn, Ameen, Nadia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031467/
https://www.ncbi.nlm.nih.gov/pubmed/36967909
http://dx.doi.org/10.1016/j.heliyon.2023.e14568
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author Carlos dos Reis, Diego
Dastoor, Parinaz
Santos, Anderson Kenedy
Sumigray, Kaelyn
Ameen, Nadia A.
author_facet Carlos dos Reis, Diego
Dastoor, Parinaz
Santos, Anderson Kenedy
Sumigray, Kaelyn
Ameen, Nadia A.
author_sort Carlos dos Reis, Diego
collection PubMed
description Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl(−)/HCO(3)(−) channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many gastrointestinal diseases. Defects in CFTR lead to intestinal dysfunction, malabsorption, obstruction, infection, inflammation, and cancer that increases morbidity and reduces quality of life. This review will focus on CFTR in the intestine and the implications of the subpopulation of CFTR High Expresser Cells (CHEs) in Cystic Fibrosis (CF), intestinal physiology and pathophysiology of intestinal diseases.
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spelling pubmed-100314672023-03-23 CFTR High Expresser Cells in cystic fibrosis and intestinal diseases Carlos dos Reis, Diego Dastoor, Parinaz Santos, Anderson Kenedy Sumigray, Kaelyn Ameen, Nadia A. Heliyon Review Article Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl(−)/HCO(3)(−) channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many gastrointestinal diseases. Defects in CFTR lead to intestinal dysfunction, malabsorption, obstruction, infection, inflammation, and cancer that increases morbidity and reduces quality of life. This review will focus on CFTR in the intestine and the implications of the subpopulation of CFTR High Expresser Cells (CHEs) in Cystic Fibrosis (CF), intestinal physiology and pathophysiology of intestinal diseases. Elsevier 2023-03-14 /pmc/articles/PMC10031467/ /pubmed/36967909 http://dx.doi.org/10.1016/j.heliyon.2023.e14568 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Carlos dos Reis, Diego
Dastoor, Parinaz
Santos, Anderson Kenedy
Sumigray, Kaelyn
Ameen, Nadia A.
CFTR High Expresser Cells in cystic fibrosis and intestinal diseases
title CFTR High Expresser Cells in cystic fibrosis and intestinal diseases
title_full CFTR High Expresser Cells in cystic fibrosis and intestinal diseases
title_fullStr CFTR High Expresser Cells in cystic fibrosis and intestinal diseases
title_full_unstemmed CFTR High Expresser Cells in cystic fibrosis and intestinal diseases
title_short CFTR High Expresser Cells in cystic fibrosis and intestinal diseases
title_sort cftr high expresser cells in cystic fibrosis and intestinal diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031467/
https://www.ncbi.nlm.nih.gov/pubmed/36967909
http://dx.doi.org/10.1016/j.heliyon.2023.e14568
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