Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish

The Keap1–Nrf2 pathway is an evolutionarily conserved mechanism that protects cells from oxidative stress and electrophiles. Keap1 is a repressor of Nrf2 in normal cellular conditions but also a stress sensor for Nrf2 activation. Interestingly, fish and amphibians have two Keap1s (Keap1a and Keap1b)...

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Detalles Bibliográficos
Autores principales: Bian, Lixuan, Nguyen, Vu Thanh, Tamaoki, Junya, Endo, Yuka, Dong, Guilin, Sato, Ayaka, Kobayashi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031532/
https://www.ncbi.nlm.nih.gov/pubmed/36934645
http://dx.doi.org/10.1016/j.redox.2023.102673

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