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One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication
[Image: see text] Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031565/ https://www.ncbi.nlm.nih.gov/pubmed/36862938 http://dx.doi.org/10.1021/acsabm.2c01080 |
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author | Brezhnev, Alexander Tang, Fung-Kit Kwan, Chak-Shing Basabrain, Mohammed S. Tsoi, James Kit Hon Matinlinna, Jukka P. Neelakantan, Prasanna Leung, Ken Cham-Fai |
author_facet | Brezhnev, Alexander Tang, Fung-Kit Kwan, Chak-Shing Basabrain, Mohammed S. Tsoi, James Kit Hon Matinlinna, Jukka P. Neelakantan, Prasanna Leung, Ken Cham-Fai |
author_sort | Brezhnev, Alexander |
collection | PubMed |
description | [Image: see text] Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials. |
format | Online Article Text |
id | pubmed-10031565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100315652023-03-23 One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication Brezhnev, Alexander Tang, Fung-Kit Kwan, Chak-Shing Basabrain, Mohammed S. Tsoi, James Kit Hon Matinlinna, Jukka P. Neelakantan, Prasanna Leung, Ken Cham-Fai ACS Appl Bio Mater [Image: see text] Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials. American Chemical Society 2023-03-02 /pmc/articles/PMC10031565/ /pubmed/36862938 http://dx.doi.org/10.1021/acsabm.2c01080 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brezhnev, Alexander Tang, Fung-Kit Kwan, Chak-Shing Basabrain, Mohammed S. Tsoi, James Kit Hon Matinlinna, Jukka P. Neelakantan, Prasanna Leung, Ken Cham-Fai One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication |
title | One-Pot Preparation
of Cetylpyridinium Chloride-Containing
Nanoparticles for Biofilm Eradication |
title_full | One-Pot Preparation
of Cetylpyridinium Chloride-Containing
Nanoparticles for Biofilm Eradication |
title_fullStr | One-Pot Preparation
of Cetylpyridinium Chloride-Containing
Nanoparticles for Biofilm Eradication |
title_full_unstemmed | One-Pot Preparation
of Cetylpyridinium Chloride-Containing
Nanoparticles for Biofilm Eradication |
title_short | One-Pot Preparation
of Cetylpyridinium Chloride-Containing
Nanoparticles for Biofilm Eradication |
title_sort | one-pot preparation
of cetylpyridinium chloride-containing
nanoparticles for biofilm eradication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031565/ https://www.ncbi.nlm.nih.gov/pubmed/36862938 http://dx.doi.org/10.1021/acsabm.2c01080 |
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