Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System

[Image: see text] Drug-responsive T-cells are activated with the parent compound or metabolites, often via different pathways (pharmacological interaction and hapten). An obstacle to the investigation of drug hypersensitivity is the scarcity of reactive metabolites for functional studies and the abs...

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Detalles Bibliográficos
Autores principales: Ali, Serat-E, Meng, Xiaoli, Kafu, Laila, Hammond, Sean, Zhao, Qing, Ogese, Monday, Sison-Young, Rowena, Jones, Robert, Chan, Benjamin, Livoti, Lucia, Sun, Yonghu, Sun, Lele, Liu, Hong, Topping, Anthony, Goldring, Christopher, Zhang, Furen, Naisbitt, Dean John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031640/
https://www.ncbi.nlm.nih.gov/pubmed/36812109
http://dx.doi.org/10.1021/acs.chemrestox.2c00343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031640/
https://www.ncbi.nlm.nih.gov/pubmed/36812109
http://dx.doi.org/10.1021/acs.chemrestox.2c00343

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