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Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
[Image: see text] Drug-responsive T-cells are activated with the parent compound or metabolites, often via different pathways (pharmacological interaction and hapten). An obstacle to the investigation of drug hypersensitivity is the scarcity of reactive metabolites for functional studies and the abs...
Autores principales: | Ali, Serat-E, Meng, Xiaoli, Kafu, Laila, Hammond, Sean, Zhao, Qing, Ogese, Monday, Sison-Young, Rowena, Jones, Robert, Chan, Benjamin, Livoti, Lucia, Sun, Yonghu, Sun, Lele, Liu, Hong, Topping, Anthony, Goldring, Christopher, Zhang, Furen, Naisbitt, Dean John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031640/ https://www.ncbi.nlm.nih.gov/pubmed/36812109 http://dx.doi.org/10.1021/acs.chemrestox.2c00343 |
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