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Safety and efficacy of co-administration of CD19 and CD22 CAR-T cells in children with B-ALL relapse after CD19 CAR-T therapy

BACKGROUND: CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable efficacy in treating relapsed or refractory pediatric B-lineage acute lymphoblastic leukemia (B-ALL). However, poor results are obtained when the same product is reused in patients who relapse after CAR-T...

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Detalles Bibliográficos
Autores principales:	Li, Wenjie, Ding, Lixia, Shi, Wenhua, Wan, Xinyu, Yang, Xiaomin, Yang, Jing, Wang, Tianyi, Song, Lili, Wang, Xiang, Ma, Yani, Luo, Chengjuan, Tang, Jingyan, Gu, Longjun, Chen, Jing, Lu, Jun, Tang, Yanjing, Li, Benshang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031882/ https://www.ncbi.nlm.nih.gov/pubmed/36949487 http://dx.doi.org/10.1186/s12967-023-04019-4

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