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The oral microbiome in autoimmune diseases: friend or foe?

The human body is colonized by abundant and diverse microorganisms, collectively known as the microbiome. The oral cavity has more than 700 species of bacteria and consists of unique microbiome niches on mucosal surfaces, on tooth hard tissue, and in saliva. The homeostatic balance between the oral...

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Autores principales: Huang, Xiaoyan, Huang, Xiangyu, Huang, Yi, Zheng, Jiarong, Lu, Ye, Mai, Zizhao, Zhao, Xinyuan, Cui, Li, Huang, Shaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031900/
https://www.ncbi.nlm.nih.gov/pubmed/36949458
http://dx.doi.org/10.1186/s12967-023-03995-x
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author Huang, Xiaoyan
Huang, Xiangyu
Huang, Yi
Zheng, Jiarong
Lu, Ye
Mai, Zizhao
Zhao, Xinyuan
Cui, Li
Huang, Shaohong
author_facet Huang, Xiaoyan
Huang, Xiangyu
Huang, Yi
Zheng, Jiarong
Lu, Ye
Mai, Zizhao
Zhao, Xinyuan
Cui, Li
Huang, Shaohong
author_sort Huang, Xiaoyan
collection PubMed
description The human body is colonized by abundant and diverse microorganisms, collectively known as the microbiome. The oral cavity has more than 700 species of bacteria and consists of unique microbiome niches on mucosal surfaces, on tooth hard tissue, and in saliva. The homeostatic balance between the oral microbiota and the immune system plays an indispensable role in maintaining the well-being and health status of the human host. Growing evidence has demonstrated that oral microbiota dysbiosis is actively involved in regulating the initiation and progression of an array of autoimmune diseases. Oral microbiota dysbiosis is driven by multiple factors, such as host genetic factors, dietary habits, stress, smoking, administration of antibiotics, tissue injury and infection. The dysregulation in the oral microbiome plays a crucial role in triggering and promoting autoimmune diseases via several mechanisms, including microbial translocation, molecular mimicry, autoantigen overproduction, and amplification of autoimmune responses by cytokines. Good oral hygiene behaviors, low carbohydrate diets, healthy lifestyles, usage of prebiotics, probiotics or synbiotics, oral microbiota transplantation and nanomedicine-based therapeutics are promising avenues for maintaining a balanced oral microbiome and treating oral microbiota-mediated autoimmune diseases. Thus, a comprehensive understanding of the relationship between oral microbiota dysbiosis and autoimmune diseases is critical for providing novel insights into the development of oral microbiota-based therapeutic approaches for combating these refractory diseases.
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spelling pubmed-100319002023-03-23 The oral microbiome in autoimmune diseases: friend or foe? Huang, Xiaoyan Huang, Xiangyu Huang, Yi Zheng, Jiarong Lu, Ye Mai, Zizhao Zhao, Xinyuan Cui, Li Huang, Shaohong J Transl Med Review The human body is colonized by abundant and diverse microorganisms, collectively known as the microbiome. The oral cavity has more than 700 species of bacteria and consists of unique microbiome niches on mucosal surfaces, on tooth hard tissue, and in saliva. The homeostatic balance between the oral microbiota and the immune system plays an indispensable role in maintaining the well-being and health status of the human host. Growing evidence has demonstrated that oral microbiota dysbiosis is actively involved in regulating the initiation and progression of an array of autoimmune diseases. Oral microbiota dysbiosis is driven by multiple factors, such as host genetic factors, dietary habits, stress, smoking, administration of antibiotics, tissue injury and infection. The dysregulation in the oral microbiome plays a crucial role in triggering and promoting autoimmune diseases via several mechanisms, including microbial translocation, molecular mimicry, autoantigen overproduction, and amplification of autoimmune responses by cytokines. Good oral hygiene behaviors, low carbohydrate diets, healthy lifestyles, usage of prebiotics, probiotics or synbiotics, oral microbiota transplantation and nanomedicine-based therapeutics are promising avenues for maintaining a balanced oral microbiome and treating oral microbiota-mediated autoimmune diseases. Thus, a comprehensive understanding of the relationship between oral microbiota dysbiosis and autoimmune diseases is critical for providing novel insights into the development of oral microbiota-based therapeutic approaches for combating these refractory diseases. BioMed Central 2023-03-22 /pmc/articles/PMC10031900/ /pubmed/36949458 http://dx.doi.org/10.1186/s12967-023-03995-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Xiaoyan
Huang, Xiangyu
Huang, Yi
Zheng, Jiarong
Lu, Ye
Mai, Zizhao
Zhao, Xinyuan
Cui, Li
Huang, Shaohong
The oral microbiome in autoimmune diseases: friend or foe?
title The oral microbiome in autoimmune diseases: friend or foe?
title_full The oral microbiome in autoimmune diseases: friend or foe?
title_fullStr The oral microbiome in autoimmune diseases: friend or foe?
title_full_unstemmed The oral microbiome in autoimmune diseases: friend or foe?
title_short The oral microbiome in autoimmune diseases: friend or foe?
title_sort oral microbiome in autoimmune diseases: friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031900/
https://www.ncbi.nlm.nih.gov/pubmed/36949458
http://dx.doi.org/10.1186/s12967-023-03995-x
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