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Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study

BACKGROUND: Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution to increasing the risk of diabetes. But few prospective studies have investigated the association between the loss of muscle mass and the occurrence of dia...

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Autores principales: Xu, Yiting, Hu, Tingting, Shen, Yun, Wang, Yufei, Bao, Yuqian, Ma, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031974/
https://www.ncbi.nlm.nih.gov/pubmed/36945053
http://dx.doi.org/10.1186/s13098-023-01027-8
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author Xu, Yiting
Hu, Tingting
Shen, Yun
Wang, Yufei
Bao, Yuqian
Ma, Xiaojing
author_facet Xu, Yiting
Hu, Tingting
Shen, Yun
Wang, Yufei
Bao, Yuqian
Ma, Xiaojing
author_sort Xu, Yiting
collection PubMed
description BACKGROUND: Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution to increasing the risk of diabetes. But few prospective studies have investigated the association between the loss of muscle mass and the occurrence of diabetes. We aimed to investigate whether short-term changes in muscle mass affect the incidence of diabetes in a Chinese population. METHODS: This study included 1275 individuals without evident diabetes at baseline. In the baseline and re-examination, individuals completed the risk factors survey and underwent body composition measurement. Muscle mass index was defined as the percentage skeletal muscle mass, which was measured by an automatic bioelectric analyzer. RESULTS: After a median follow-up of 2.1 years, 142 individuals developed diabetes (11.1%). There was an inverse association between basal skeletal muscle mass index and the risk of diabetes in participants with impaired glucose regulation but not in those with normal glucose tolerance. Multivariate-adjusted hazard ratios for the risk of developing diabetes were 0.85 (95% CI: 0.74–0.98) and 1.15 (95% CI: 0.98–1.34), respectively. Furthermore, Cox regression analysis revealed that a two-year change in skeletal muscle mass was also inversely associated with the incidence of diabetes in both participants with normal glucose tolerance and with impaired glucose regulation (HR: 0.76, 95% CI: 0.65–0.89; HR: 0.81, 95% CI: 0.71–0.91). CONCLUSIONS: These findings emphasized the importance of early detection and control of muscle mass loss for the prevention of diabetes.
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spelling pubmed-100319742023-03-23 Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study Xu, Yiting Hu, Tingting Shen, Yun Wang, Yufei Bao, Yuqian Ma, Xiaojing Diabetol Metab Syndr Research BACKGROUND: Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution to increasing the risk of diabetes. But few prospective studies have investigated the association between the loss of muscle mass and the occurrence of diabetes. We aimed to investigate whether short-term changes in muscle mass affect the incidence of diabetes in a Chinese population. METHODS: This study included 1275 individuals without evident diabetes at baseline. In the baseline and re-examination, individuals completed the risk factors survey and underwent body composition measurement. Muscle mass index was defined as the percentage skeletal muscle mass, which was measured by an automatic bioelectric analyzer. RESULTS: After a median follow-up of 2.1 years, 142 individuals developed diabetes (11.1%). There was an inverse association between basal skeletal muscle mass index and the risk of diabetes in participants with impaired glucose regulation but not in those with normal glucose tolerance. Multivariate-adjusted hazard ratios for the risk of developing diabetes were 0.85 (95% CI: 0.74–0.98) and 1.15 (95% CI: 0.98–1.34), respectively. Furthermore, Cox regression analysis revealed that a two-year change in skeletal muscle mass was also inversely associated with the incidence of diabetes in both participants with normal glucose tolerance and with impaired glucose regulation (HR: 0.76, 95% CI: 0.65–0.89; HR: 0.81, 95% CI: 0.71–0.91). CONCLUSIONS: These findings emphasized the importance of early detection and control of muscle mass loss for the prevention of diabetes. BioMed Central 2023-03-22 /pmc/articles/PMC10031974/ /pubmed/36945053 http://dx.doi.org/10.1186/s13098-023-01027-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Xu, Yiting
Hu, Tingting
Shen, Yun
Wang, Yufei
Bao, Yuqian
Ma, Xiaojing
Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
title Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
title_full Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
title_fullStr Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
title_full_unstemmed Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
title_short Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
title_sort association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031974/
https://www.ncbi.nlm.nih.gov/pubmed/36945053
http://dx.doi.org/10.1186/s13098-023-01027-8
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