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Single-cell and spatial transcriptomics during human organogenesis

The molecular and cellular events that occur during the onset of human organogenesis remain mysterious. We used single-cell and spatial transcriptomics to provide a global view of human embryonic cell-type specification, shedding light on developmental processes such as axial patterning, stage trans...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032247/
https://www.ncbi.nlm.nih.gov/pubmed/36949166
http://dx.doi.org/10.1038/s41556-023-01113-z
Descripción
Sumario:The molecular and cellular events that occur during the onset of human organogenesis remain mysterious. We used single-cell and spatial transcriptomics to provide a global view of human embryonic cell-type specification, shedding light on developmental processes such as axial patterning, stage transition, and differences between human and mouse embryonic development.