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Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1

The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall(1,2). FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp(3,4). Unfortunately, the mechanism of action of FKS remains enigmat...

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Detalles Bibliográficos
Autores principales:	Hu, Xinlin, Yang, Ping, Chai, Changdong, Liu, Jia, Sun, Huanhuan, Wu, Yanan, Zhang, Mingjie, Zhang, Min, Liu, Xiaotian, Yu, Hongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032269/ https://www.ncbi.nlm.nih.gov/pubmed/36949198 http://dx.doi.org/10.1038/s41586-023-05856-5

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