Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome

Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses amon...

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Autores principales: Behluli, Emir, Nuhii, Nexhibe, Liehr, Thomas, Temaj, Gazmend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2022
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032328/
https://www.ncbi.nlm.nih.gov/pubmed/35853737
http://dx.doi.org/10.34763/jmotherandchild.20222601.d-22-00002
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author Behluli, Emir
Nuhii, Nexhibe
Liehr, Thomas
Temaj, Gazmend
author_facet Behluli, Emir
Nuhii, Nexhibe
Liehr, Thomas
Temaj, Gazmend
author_sort Behluli, Emir
collection PubMed
description Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients.
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spelling pubmed-100323282023-03-23 Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome Behluli, Emir Nuhii, Nexhibe Liehr, Thomas Temaj, Gazmend J Mother Child Review Articles Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients. Sciendo 2022-07-20 /pmc/articles/PMC10032328/ /pubmed/35853737 http://dx.doi.org/10.34763/jmotherandchild.20222601.d-22-00002 Text en © 2022 Emir Behluli et al., published by Sciendo https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review Articles
Behluli, Emir
Nuhii, Nexhibe
Liehr, Thomas
Temaj, Gazmend
Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
title Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
title_full Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
title_fullStr Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
title_full_unstemmed Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
title_short Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
title_sort suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032328/
https://www.ncbi.nlm.nih.gov/pubmed/35853737
http://dx.doi.org/10.34763/jmotherandchild.20222601.d-22-00002
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