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Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review
Lichen myxedematosus (LM) is an idiopathic cutaneous mucinosis disorder, and monoclonal gammopathy of undetermined significance (MGUS) is a preneoplastic plasma cell disease with a monoclonal increase in globulin. Patients with LM combined with monoclonal gammopathy are normally diagnosed with scler...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032400/ https://www.ncbi.nlm.nih.gov/pubmed/36968834 http://dx.doi.org/10.3389/fmed.2023.1118555 |
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author | Huang, Hua Qian, Shen-Xian |
author_facet | Huang, Hua Qian, Shen-Xian |
author_sort | Huang, Hua |
collection | PubMed |
description | Lichen myxedematosus (LM) is an idiopathic cutaneous mucinosis disorder, and monoclonal gammopathy of undetermined significance (MGUS) is a preneoplastic plasma cell disease with a monoclonal increase in globulin. Patients with LM combined with monoclonal gammopathy are normally diagnosed with scleromyxedema. However, we report a case of generalized papules combined with MGUS in a 78-year-old man who was eventually diagnosed with atypical or intermediate forms of LM because it only involved the skin, and the pathological type was not consistent with scleromyxedema. Few cases of atypical or intermediate forms of LM have been reported, so the course of atypical or intermediate forms of LM is unpredictable. We report the diagnosis and treatment of a case of atypical forms of LM to discuss the current understanding of the disease, hoping to provide a reference for clinical research on this disease. |
format | Online Article Text |
id | pubmed-10032400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100324002023-03-23 Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review Huang, Hua Qian, Shen-Xian Front Med (Lausanne) Medicine Lichen myxedematosus (LM) is an idiopathic cutaneous mucinosis disorder, and monoclonal gammopathy of undetermined significance (MGUS) is a preneoplastic plasma cell disease with a monoclonal increase in globulin. Patients with LM combined with monoclonal gammopathy are normally diagnosed with scleromyxedema. However, we report a case of generalized papules combined with MGUS in a 78-year-old man who was eventually diagnosed with atypical or intermediate forms of LM because it only involved the skin, and the pathological type was not consistent with scleromyxedema. Few cases of atypical or intermediate forms of LM have been reported, so the course of atypical or intermediate forms of LM is unpredictable. We report the diagnosis and treatment of a case of atypical forms of LM to discuss the current understanding of the disease, hoping to provide a reference for clinical research on this disease. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10032400/ /pubmed/36968834 http://dx.doi.org/10.3389/fmed.2023.1118555 Text en Copyright © 2023 Huang and Qian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Huang, Hua Qian, Shen-Xian Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review |
title | Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review |
title_full | Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review |
title_fullStr | Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review |
title_full_unstemmed | Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review |
title_short | Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review |
title_sort | lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: a case report and literature review |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032400/ https://www.ncbi.nlm.nih.gov/pubmed/36968834 http://dx.doi.org/10.3389/fmed.2023.1118555 |
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