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How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use

The Organization for Economic Co-operation and Development (OECD) Guidance Document No. 34 and No. 286 on Good In Vitro Method Practices (GIVIMPs) for the development and implementation of in vitro methods for regulatory use in human safety assessment have been endorsed. Considering that China is ac...

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Autores principales: Liu, Yanfeng, Cai, Zhenzi, Li, Nan, Alépée, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032455/
https://www.ncbi.nlm.nih.gov/pubmed/36969263
http://dx.doi.org/10.3389/ftox.2023.1080528
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author Liu, Yanfeng
Cai, Zhenzi
Li, Nan
Alépée, Nathalie
author_facet Liu, Yanfeng
Cai, Zhenzi
Li, Nan
Alépée, Nathalie
author_sort Liu, Yanfeng
collection PubMed
description The Organization for Economic Co-operation and Development (OECD) Guidance Document No. 34 and No. 286 on Good In Vitro Method Practices (GIVIMPs) for the development and implementation of in vitro methods for regulatory use in human safety assessment have been endorsed. Considering that China is accelerating the development of alternative approaches in both research and acceptance, early application of these principles is beneficial to the implementation and acceptance of in vitro alternative methods in China. To promote the replacement of animal testing for regulatory use, L’Oréal initiated the EpiSkin™ skin irritation test (SIT) implementation program in China. More than 50 external scientists participated, and the method has been established in 34 organizations including authorities, industries, and testing service laboratories. Taking two collaborations with Guangdong CDC and Shanghai SGS for in vitro SIT as examples, we demonstrated a method implementation process in good alignment with the OECD principles. The current study illustrated the practical way in which both OECD Guidance documents assisted in the transfer and establishment of in vitro approaches and further promoted the future scientific recognition and acceptance of new OECD-accepted alternative testing methodologies in China.
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spelling pubmed-100324552023-03-23 How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use Liu, Yanfeng Cai, Zhenzi Li, Nan Alépée, Nathalie Front Toxicol Toxicology The Organization for Economic Co-operation and Development (OECD) Guidance Document No. 34 and No. 286 on Good In Vitro Method Practices (GIVIMPs) for the development and implementation of in vitro methods for regulatory use in human safety assessment have been endorsed. Considering that China is accelerating the development of alternative approaches in both research and acceptance, early application of these principles is beneficial to the implementation and acceptance of in vitro alternative methods in China. To promote the replacement of animal testing for regulatory use, L’Oréal initiated the EpiSkin™ skin irritation test (SIT) implementation program in China. More than 50 external scientists participated, and the method has been established in 34 organizations including authorities, industries, and testing service laboratories. Taking two collaborations with Guangdong CDC and Shanghai SGS for in vitro SIT as examples, we demonstrated a method implementation process in good alignment with the OECD principles. The current study illustrated the practical way in which both OECD Guidance documents assisted in the transfer and establishment of in vitro approaches and further promoted the future scientific recognition and acceptance of new OECD-accepted alternative testing methodologies in China. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10032455/ /pubmed/36969263 http://dx.doi.org/10.3389/ftox.2023.1080528 Text en Copyright © 2023 Liu, Cai, Li and Alépée. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Toxicology
Liu, Yanfeng
Cai, Zhenzi
Li, Nan
Alépée, Nathalie
How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use
title How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use
title_full How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use
title_fullStr How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use
title_full_unstemmed How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use
title_short How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use
title_sort how to facilitate the implementation of 3d models in china by applying good in vitro method practice for regulatory use
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032455/
https://www.ncbi.nlm.nih.gov/pubmed/36969263
http://dx.doi.org/10.3389/ftox.2023.1080528
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