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Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study

[Image: see text] Phosphorylation, the most popular post-translational modification of tau protein, plays an important role in regulating tau physiological functions. However, aberrant phosphorylation attenuates the binding affinity of tau to a microtubule (MT), resulting in MT destabilization follo...

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Detalles Bibliográficos
Autores principales:	Man, Viet Hoang, He, Xibing, Gao, Jie, Wang, Junmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032563/ https://www.ncbi.nlm.nih.gov/pubmed/36669127 http://dx.doi.org/10.1021/acschemneuro.2c00611

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