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Lung transplantation for COPD/pulmonary emphysema

COPD and α-1 antitrypsin deficiency emphysema remain one of the major indications for lung transplantation. If all other treatment possibilities are exhausted or not possible (including rehabilitation, oxygen therapy, noninvasive ventilation, lung volume reduction), patients may qualify for lung tra...

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Detalles Bibliográficos
Autores principales: Verleden, Geert M., Gottlieb, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032585/
https://www.ncbi.nlm.nih.gov/pubmed/36948499
http://dx.doi.org/10.1183/16000617.0116-2022
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author Verleden, Geert M.
Gottlieb, Jens
author_facet Verleden, Geert M.
Gottlieb, Jens
author_sort Verleden, Geert M.
collection PubMed
description COPD and α-1 antitrypsin deficiency emphysema remain one of the major indications for lung transplantation. If all other treatment possibilities are exhausted or not possible (including rehabilitation, oxygen therapy, noninvasive ventilation, lung volume reduction), patients may qualify for lung transplantation. Strict selection criteria are implemented with a lot of relative and absolute contraindications. Because of an ongoing donor shortage, only a minority of endstage COPD patients will finally get transplanted. The procedure may involve a single or a double lung transplantation, dependent on the experience of the centre, the waiting list, the availability of donor lungs and the patient's risk–benefit ratio. In general, the life expectancy as well as the health-related quality of life after lung transplantation for COPD are usually increased, and may be somewhat better after double compared with single lung transplantation. Several specific complications can be encountered, such as the development of solid organ cancer and chronic lung allograft dysfunction, which develops in up to 50% of patients within 5 years of their transplant and has a major impact on long-term survival, because of the current inefficient treatment modalities.
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spelling pubmed-100325852023-03-23 Lung transplantation for COPD/pulmonary emphysema Verleden, Geert M. Gottlieb, Jens Eur Respir Rev Series COPD and α-1 antitrypsin deficiency emphysema remain one of the major indications for lung transplantation. If all other treatment possibilities are exhausted or not possible (including rehabilitation, oxygen therapy, noninvasive ventilation, lung volume reduction), patients may qualify for lung transplantation. Strict selection criteria are implemented with a lot of relative and absolute contraindications. Because of an ongoing donor shortage, only a minority of endstage COPD patients will finally get transplanted. The procedure may involve a single or a double lung transplantation, dependent on the experience of the centre, the waiting list, the availability of donor lungs and the patient's risk–benefit ratio. In general, the life expectancy as well as the health-related quality of life after lung transplantation for COPD are usually increased, and may be somewhat better after double compared with single lung transplantation. Several specific complications can be encountered, such as the development of solid organ cancer and chronic lung allograft dysfunction, which develops in up to 50% of patients within 5 years of their transplant and has a major impact on long-term survival, because of the current inefficient treatment modalities. European Respiratory Society 2023-03-22 /pmc/articles/PMC10032585/ /pubmed/36948499 http://dx.doi.org/10.1183/16000617.0116-2022 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Series
Verleden, Geert M.
Gottlieb, Jens
Lung transplantation for COPD/pulmonary emphysema
title Lung transplantation for COPD/pulmonary emphysema
title_full Lung transplantation for COPD/pulmonary emphysema
title_fullStr Lung transplantation for COPD/pulmonary emphysema
title_full_unstemmed Lung transplantation for COPD/pulmonary emphysema
title_short Lung transplantation for COPD/pulmonary emphysema
title_sort lung transplantation for copd/pulmonary emphysema
topic Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032585/
https://www.ncbi.nlm.nih.gov/pubmed/36948499
http://dx.doi.org/10.1183/16000617.0116-2022
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