Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy

Immunoglobulin A (IgA) nephropathy (IgAN) is the most common type of primary glomerulonephritis, often progressing to renal failure. IgAN is triggered by IgA deposition in the glomerular mesangium by an undefined mechanism. Here, we show that grouped ddY (gddY) mice, a spontaneous IgAN model, produc...

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Detalles Bibliográficos
Autores principales: Nihei, Yoshihito, Haniuda, Kei, Higashiyama, Mizuki, Asami, Shohei, Iwasaki, Hiroyuki, Fukao, Yusuke, Nakayama, Maiko, Suzuki, Hitoshi, Kikkawa, Mika, Kazuno, Saiko, Miura, Yoshiki, Suzuki, Yusuke, Kitamura, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032602/
https://www.ncbi.nlm.nih.gov/pubmed/36947618
http://dx.doi.org/10.1126/sciadv.add6734

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