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Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit

Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of the exposure. Such a postexposure anxiogenic effect depended upon melanopsin-ba...

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Autores principales: Wang, Ge, Liu, Yun-Feng, Yang, Zhe, Yu, Chen-Xi, Tong, Qiuping, Tang, Yu-Long, Shao, Yu-Qi, Wang, Li-Qin, Xu, Xun, Cao, Hong, Zhang, Yu-Qiu, Zhong, Yong-Mei, Weng, Shi-Jun, Yang, Xiong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032603/
https://www.ncbi.nlm.nih.gov/pubmed/36947616
http://dx.doi.org/10.1126/sciadv.adf4651
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author Wang, Ge
Liu, Yun-Feng
Yang, Zhe
Yu, Chen-Xi
Tong, Qiuping
Tang, Yu-Long
Shao, Yu-Qi
Wang, Li-Qin
Xu, Xun
Cao, Hong
Zhang, Yu-Qiu
Zhong, Yong-Mei
Weng, Shi-Jun
Yang, Xiong-Li
author_facet Wang, Ge
Liu, Yun-Feng
Yang, Zhe
Yu, Chen-Xi
Tong, Qiuping
Tang, Yu-Long
Shao, Yu-Qi
Wang, Li-Qin
Xu, Xun
Cao, Hong
Zhang, Yu-Qiu
Zhong, Yong-Mei
Weng, Shi-Jun
Yang, Xiong-Li
author_sort Wang, Ge
collection PubMed
description Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of the exposure. Such a postexposure anxiogenic effect depended upon melanopsin-based intrinsically photosensitive retinal ganglion cell (ipRGC) activities rather than rod/cone photoreceptor inputs. Chemogenetic manipulation of specific central nuclei demonstrated that the ipRGC–central amygdala (CeA) visual circuit played a key role in this effect. The corticosterone system was likely to be involved in this effect, as evidenced by enhanced expression of the glucocorticoid receptor (GR) protein in the CeA and the bed nucleus of the stria terminalis and by the absence of this effect in animals treated with the GR antagonist. Together, our findings reveal a non-image forming visual circuit specifically designed for “the delayed” extinction of anxiety against potential threats, thus conferring a survival advantage.
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spelling pubmed-100326032023-03-23 Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit Wang, Ge Liu, Yun-Feng Yang, Zhe Yu, Chen-Xi Tong, Qiuping Tang, Yu-Long Shao, Yu-Qi Wang, Li-Qin Xu, Xun Cao, Hong Zhang, Yu-Qiu Zhong, Yong-Mei Weng, Shi-Jun Yang, Xiong-Li Sci Adv Neuroscience Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of the exposure. Such a postexposure anxiogenic effect depended upon melanopsin-based intrinsically photosensitive retinal ganglion cell (ipRGC) activities rather than rod/cone photoreceptor inputs. Chemogenetic manipulation of specific central nuclei demonstrated that the ipRGC–central amygdala (CeA) visual circuit played a key role in this effect. The corticosterone system was likely to be involved in this effect, as evidenced by enhanced expression of the glucocorticoid receptor (GR) protein in the CeA and the bed nucleus of the stria terminalis and by the absence of this effect in animals treated with the GR antagonist. Together, our findings reveal a non-image forming visual circuit specifically designed for “the delayed” extinction of anxiety against potential threats, thus conferring a survival advantage. American Association for the Advancement of Science 2023-03-22 /pmc/articles/PMC10032603/ /pubmed/36947616 http://dx.doi.org/10.1126/sciadv.adf4651 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Wang, Ge
Liu, Yun-Feng
Yang, Zhe
Yu, Chen-Xi
Tong, Qiuping
Tang, Yu-Long
Shao, Yu-Qi
Wang, Li-Qin
Xu, Xun
Cao, Hong
Zhang, Yu-Qiu
Zhong, Yong-Mei
Weng, Shi-Jun
Yang, Xiong-Li
Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
title Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
title_full Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
title_fullStr Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
title_full_unstemmed Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
title_short Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit
title_sort short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal iprgc-cea circuit
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032603/
https://www.ncbi.nlm.nih.gov/pubmed/36947616
http://dx.doi.org/10.1126/sciadv.adf4651
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