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Energy landscapes of Aβ monomers are sculpted in accordance with Ostwald’s rule of stages
The transition from a disordered to an assembly-competent monomeric state (N*) in amyloidogenic sequences is a crucial event in the aggregation cascade. Using a well-calibrated model for intrinsically disordered proteins (IDPs), we show that the N* states, which bear considerable resemblance to the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032606/ https://www.ncbi.nlm.nih.gov/pubmed/36947617 http://dx.doi.org/10.1126/sciadv.add6921 |