Mutation of a distal gating residue modulates NADH binding in NADH:Quinone oxidoreductase from Pseudomonas aeruginosa PAO1

Enzymes require flexible regions to adopt multiple conformations during catalysis. The mobile regions of enzymes include gates that modulate the passage of molecules in and out of the enzyme's active site. The enzyme PA1024 from Pseudomonas aeruginosa PA01 is a recently discovered flavin-depend...

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Detalles Bibliográficos
Autores principales: Moni, Bilkis Mehrin, Quaye, Joanna A., Gadda, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033279/
https://www.ncbi.nlm.nih.gov/pubmed/36803963
http://dx.doi.org/10.1016/j.jbc.2023.103044

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