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Optimization of FK-506 production in Streptomyces tsukubaensis by modulation of Crp-mediated regulation

ABSTRACT: FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological production of FK-506 is rather limited. Optimization strategies to enhan...

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Detalles Bibliográficos
Autores principales:	Schulz, Susann, Sletta, Håvard, Fløgstad Degnes, Kristin, Krysenko, Sergii, Williams, Alicia, Olsen, Silje Malene, Vernstad, Kai, Mitulski, Agnieszka, Wohlleben, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Biotechnological Products and Process Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033298/ https://www.ncbi.nlm.nih.gov/pubmed/36949330 http://dx.doi.org/10.1007/s00253-023-12473-9

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