Cargando…

Antiviral drugs block replication of highly immune-evasive Omicron subvariants ex vivo, but fail to reduce tissue inflammation

The identification of the SARS-CoV-2 Omicron variants BA.4/BA.5, BF.7 and BQ.1.1 immediately raised concerns regarding the efficacy of currently used monoclonal antibody therapies. Here we examined the activity of monoclonal antibody therapies and antiviral drugs against clinical specimens for SARS-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dichtl, Stefanie, Diem, Gabriel, Jäger, Michael, Zaderer, Viktoria, Lupoli, Gaia, Dächert, Christopher, Muenchhoff, Maximilian, Graf, Alexander, Blum, Helmut, Keppler, Oliver T., Lass-Flörl, Cornelia, Weiss, Günter, Wilflingseder, Doris, Posch, Wilfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier B.V. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033493/ https://www.ncbi.nlm.nih.gov/pubmed/36965526 http://dx.doi.org/10.1016/j.antiviral.2023.105581

Ejemplares similares

Omicron subvariants illustrate reduced respiratory tissue penetration, cell damage and inflammatory responses in human airway epithelia
por: Zaderer, Viktoria, et al.
Publicado: (2023)

Salivary antibodies induced by BA.4/BA.5-convalescence or bivalent booster Immunoglobulin vaccination protect against novel SARS-COV-2 variants of concern
por: Diem, Gabriel, et al.
Publicado: (2023)

ColdZyme® protects airway epithelia from infection with BA.4/5
por: Viktoria, Zaderer, et al.
Publicado: (2022)

Correction: ColdZyme® protects airway epithelia from infection with BA.4/5
por: Zaderer, Viktoria, et al.
Publicado: (2023)

Vaccination and Omicron BA.1/BA.2 Convalescence Enhance Systemic but Not Mucosal Immunity against BA.4/5
por: Diem, Gabriel, et al.
Publicado: (2023)

Turning the World Upside-Down in Cellulose for Improved Culturing and Imaging of Respiratory Challenges within a Human 3D Model
por: Zaderer, Viktoria, et al.
Publicado: (2019)

Cilgavimab/Tixagevimab as alternative therapeutic approach for BA.2 infections
por: Dichtl, Stefanie, et al.
Publicado: (2022)

Dexamethasone Promotes Aspergillus fumigatus Growth in Macrophages by Triggering M2 Repolarization via Targeting PKM2
por: Luvanda, Maureen K., et al.
Publicado: (2021)

Dexamethasone Creates a Suppressive Microenvironment and Promotes Aspergillus fumigatus Invasion in a Human 3D Epithelial/Immune Respiratory Model
por: Luvanda, Maureen K., et al.
Publicado: (2021)

Immunity of Heterologously and Homologously Boosted or Convalescent Individuals Against Omicron BA.1, BA.2, and BA.4/5 Variants
por: Jäger, Michael, et al.
Publicado: (2023)

Immune Responses Against SARS-CoV-2 WT and Delta Variant in Elderly BNT162b2 Vaccinees
por: Jäger, Michael, et al.
Publicado: (2022)

Serum Neutralization Against SARS-CoV-2 Variants Is Heterogenic and Depends on Vaccination Regimen
por: Jäger, Michael, et al.
Publicado: (2022)

SARS-CoV-2–infected primary human airway epithelia illustrate mucus hypersecretion
por: Posch, Wilfried, et al.
Publicado: (2021)

Immune Evasion of SARS-CoV-2 Omicron Subvariants
por: Ke, Hanzhong, et al.
Publicado: (2022)

Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants
por: Li, Yaning, et al.
Publicado: (2023)

Salivary IgAs and Their Role in Mucosal Neutralization of SARS-CoV-2 Variants of Concern
por: Diem, Gabriel, et al.
Publicado: (2022)

Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity
por: Posch, Wilfried, et al.
Publicado: (2020)

Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB
por: Uraki, Ryuta, et al.
Publicado: (2023)

ColdZyme Maintains Integrity in SARS-CoV-2-Infected Airway Epithelia
por: Posch, W., et al.
Publicado: (2021)

GlyPerA™ effectively shields airway epithelia from SARS-CoV-2 infection and inflammatory events
por: Zaderer, Viktoria, et al.
Publicado: (2023)

Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients
por: Lafon, Eliott, et al.
Publicado: (2021)

Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern
por: Lafon, Eliott, et al.
Publicado: (2022)

Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5
por: Krenn, Franziska, et al.
Publicado: (2023)

C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia
por: Posch, Wilfried, et al.
Publicado: (2021)

The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB.1.5 and BQ.1.1 subvariants
por: Ao, Danyi, et al.
Publicado: (2023)

Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants
por: Dächert, Christopher, et al.
Publicado: (2022)

Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus infections
por: Chandorkar, P., et al.
Publicado: (2017)

Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology
por: Schöbel, H., et al.
Publicado: (2023)

P80 Natural Essence Exerts Efficient Anti-HIV-1- as Well as Adjuvant Effects in DCs
por: Zaderer, Viktoria, et al.
Publicado: (2021)

Comparable neutralisation evasion of SARS-CoV-2 omicron subvariants BA.1, BA.2, and BA.3
por: Arora, Prerna, et al.
Publicado: (2022)

Diagnostic Performance of a Novel Multiplex PCR Assay for Candidemia among ICU Patients
por: Fuchs, Stefan, et al.
Publicado: (2019)

Microbiological and Molecular Diagnosis of Mucormycosis: From Old to New
por: Lackner, Nina, et al.
Publicado: (2021)

Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
por: Posch, Wilfried, et al.
Publicado: (2021)

Neutralization sensitivity, fusogenicity, and infectivity of Omicron subvariants
por: Wang, Xue-Jun, et al.
Publicado: (2022)

Genomic evidence for reinfection with different Omicron subvariants
por: Hirotsu, Yosuke, et al.
Publicado: (2023)

Durability of Bivalent Boosters against Omicron Subvariants
por: Lin, Dan-Yu, et al.
Publicado: (2023)

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5
por: Wang, Qian, et al.
Publicado: (2022)

The Epidemiological Features of the SARS-CoV-2 Omicron Subvariant BA.5 and Its Evasion of the Neutralizing Activity of Vaccination and Prior Infection
por: Tian, Dandan, et al.
Publicado: (2022)

Detection of the Omicron BA.2.75 subvariant in Japan
por: Hirotsu, Yosuke, et al.
Publicado: (2023)

Omicron Subvariants: Clinical, Laboratory, and Cell Culture Characterization
por: Morris, C. Paul, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_msc08f2quvmak9vpojspgv6f7m