Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection

The SARS-CoV-2 coronavirus continues to evolve with scores of mutations of the spike, membrane, envelope, and nucleocapsid structural proteins that impact pathogenesis. Infection data from nasal swabs, nasal PCR assays, upper respiratory samples, ex vivo cell cultures and nasal epithelial organoids...

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Detalles Bibliográficos
Autores principales: Pearson, Jason, Wessler, Timothy, Chen, Alex, Boucher, Richard C., Freeman, Ronit, Lai, Samuel K., Pickles, Raymond, Forest, M. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033495/
https://www.ncbi.nlm.nih.gov/pubmed/36965846
http://dx.doi.org/10.1016/j.jtbi.2023.111470

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