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Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study
AIMS: To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective observational study enrolled patients with T2DM at the Second Hospital of Jilin University between December 2021...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033569/ https://www.ncbi.nlm.nih.gov/pubmed/36633709 http://dx.doi.org/10.1007/s00592-022-02028-1 |
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author | Wu, You Sun, Yunwei Wu, Yiwei Zhang, Kecheng Chen, Yan |
author_facet | Wu, You Sun, Yunwei Wu, Yiwei Zhang, Kecheng Chen, Yan |
author_sort | Wu, You |
collection | PubMed |
description | AIMS: To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective observational study enrolled patients with T2DM at the Second Hospital of Jilin University between December 2021 and March 2022. DKD was measured by the urinary albumin-to-creatinine ratio. Receiver operating characteristic curve (ROC) analysis was performed to assess the predictive value of ferroptosis-related biomarkers for DKD.The risk factors for massive proteinuria were performed by multivariable logistic regression analysis. RESULTS: Finally, 118 patients (53.0 ± 12.2 years, 76 males) were enrolled, 52 of them without DKD (had normal proteinuria), while 66 with DKD. (Forty-one had microproteinuria, and 25 had massive proteinuria.) FR biomarkers, including acyl-CoA synthase long chain family member 4 (ACSL4), malondialdehyde (MDA), and reactive oxygen species (ROS), were significantly higher in the massive proteinuria group than in the other groups, while glutathione peroxidase 4 (GPX4) was significantly lower (all P < 0.05). The area under the ROC of the combination of GPX4, ACSL4, MDA, and ROS for predicting DKD was 0.804 (P < 0.001). Additionally, multivariate logistic regression analysis showed that the course of disease and ferritin levels were independent risk factors for massive proteinuria, while high serum iron, transferrin, and GPX4 levels were independent protective factors for massive proteinuria in patients with T2DM (all P < 0.05). CONCLUSIONS: The GPX4, ACSL4, MDA, and ROS combination might have a good predictive value for DKD. Additionally, the course of disease, ferritin levels, serum iron, transferrin, and GPX4 were independently associated with massive proteinuria. |
format | Online Article Text |
id | pubmed-10033569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-100335692023-03-24 Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study Wu, You Sun, Yunwei Wu, Yiwei Zhang, Kecheng Chen, Yan Acta Diabetol Original Article AIMS: To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective observational study enrolled patients with T2DM at the Second Hospital of Jilin University between December 2021 and March 2022. DKD was measured by the urinary albumin-to-creatinine ratio. Receiver operating characteristic curve (ROC) analysis was performed to assess the predictive value of ferroptosis-related biomarkers for DKD.The risk factors for massive proteinuria were performed by multivariable logistic regression analysis. RESULTS: Finally, 118 patients (53.0 ± 12.2 years, 76 males) were enrolled, 52 of them without DKD (had normal proteinuria), while 66 with DKD. (Forty-one had microproteinuria, and 25 had massive proteinuria.) FR biomarkers, including acyl-CoA synthase long chain family member 4 (ACSL4), malondialdehyde (MDA), and reactive oxygen species (ROS), were significantly higher in the massive proteinuria group than in the other groups, while glutathione peroxidase 4 (GPX4) was significantly lower (all P < 0.05). The area under the ROC of the combination of GPX4, ACSL4, MDA, and ROS for predicting DKD was 0.804 (P < 0.001). Additionally, multivariate logistic regression analysis showed that the course of disease and ferritin levels were independent risk factors for massive proteinuria, while high serum iron, transferrin, and GPX4 levels were independent protective factors for massive proteinuria in patients with T2DM (all P < 0.05). CONCLUSIONS: The GPX4, ACSL4, MDA, and ROS combination might have a good predictive value for DKD. Additionally, the course of disease, ferritin levels, serum iron, transferrin, and GPX4 were independently associated with massive proteinuria. Springer Milan 2023-01-12 2023 /pmc/articles/PMC10033569/ /pubmed/36633709 http://dx.doi.org/10.1007/s00592-022-02028-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Wu, You Sun, Yunwei Wu, Yiwei Zhang, Kecheng Chen, Yan Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
title | Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
title_full | Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
title_fullStr | Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
title_full_unstemmed | Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
title_short | Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
title_sort | predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033569/ https://www.ncbi.nlm.nih.gov/pubmed/36633709 http://dx.doi.org/10.1007/s00592-022-02028-1 |
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