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Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies

Mucous membrane pemphigoid (MMP) is a type of subepithelial autoimmune bullous disease, affecting various mucosae, occasionally with skin lesions. Both diagnosis and treatment of MMP are difficult. Although multiple autoantigens have been identified for MMP, the pathogenesis of MMP is still unclear....

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Autores principales: Liu, Weijun, Li, Huicheng, Jin, Yun, Cheng, Lifang, Shi, Luhuai, Gao, Yangmin, Zhou, Zhijun, Feng, Suying, Qian, Hua, Hashimoto, Takashi, Li, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033602/
https://www.ncbi.nlm.nih.gov/pubmed/36969205
http://dx.doi.org/10.3389/fimmu.2023.1149119
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author Liu, Weijun
Li, Huicheng
Jin, Yun
Cheng, Lifang
Shi, Luhuai
Gao, Yangmin
Zhou, Zhijun
Feng, Suying
Qian, Hua
Hashimoto, Takashi
Li, Xiaoguang
author_facet Liu, Weijun
Li, Huicheng
Jin, Yun
Cheng, Lifang
Shi, Luhuai
Gao, Yangmin
Zhou, Zhijun
Feng, Suying
Qian, Hua
Hashimoto, Takashi
Li, Xiaoguang
author_sort Liu, Weijun
collection PubMed
description Mucous membrane pemphigoid (MMP) is a type of subepithelial autoimmune bullous disease, affecting various mucosae, occasionally with skin lesions. Both diagnosis and treatment of MMP are difficult. Although multiple autoantigens have been identified for MMP, the pathogenesis of MMP is still unclear. In this study, we presented a female MMP case with extensive oral mucosal lesions and skin lesions, particularly on the extremities. IgG and IgA autoantibodies against multiple autoantigens including BP180, laminin 332, integrinα6β4 and desmoglein 3, and IgM autoantibodies against BP180 were identified during the disease course. Compared with IgG autoantibodies, the levels of IgA autoantibodies against various autoantigens decreased more significantly with improvement of clinical features after the initiation of treatments. Our findings indicated the importance of comprehensive autoantibody screening for different immunoglobulin types and autoantigens at multiple time points for the precise diagnosis of various autoimmune bullous diseases, and the significant involvement of IgA autoantibodies into the pathogenesis of MMP.
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spelling pubmed-100336022023-03-24 Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies Liu, Weijun Li, Huicheng Jin, Yun Cheng, Lifang Shi, Luhuai Gao, Yangmin Zhou, Zhijun Feng, Suying Qian, Hua Hashimoto, Takashi Li, Xiaoguang Front Immunol Immunology Mucous membrane pemphigoid (MMP) is a type of subepithelial autoimmune bullous disease, affecting various mucosae, occasionally with skin lesions. Both diagnosis and treatment of MMP are difficult. Although multiple autoantigens have been identified for MMP, the pathogenesis of MMP is still unclear. In this study, we presented a female MMP case with extensive oral mucosal lesions and skin lesions, particularly on the extremities. IgG and IgA autoantibodies against multiple autoantigens including BP180, laminin 332, integrinα6β4 and desmoglein 3, and IgM autoantibodies against BP180 were identified during the disease course. Compared with IgG autoantibodies, the levels of IgA autoantibodies against various autoantigens decreased more significantly with improvement of clinical features after the initiation of treatments. Our findings indicated the importance of comprehensive autoantibody screening for different immunoglobulin types and autoantigens at multiple time points for the precise diagnosis of various autoimmune bullous diseases, and the significant involvement of IgA autoantibodies into the pathogenesis of MMP. Frontiers Media S.A. 2023-03-09 /pmc/articles/PMC10033602/ /pubmed/36969205 http://dx.doi.org/10.3389/fimmu.2023.1149119 Text en Copyright © 2023 Liu, Li, Jin, Cheng, Shi, Gao, Zhou, Feng, Qian, Hashimoto and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Weijun
Li, Huicheng
Jin, Yun
Cheng, Lifang
Shi, Luhuai
Gao, Yangmin
Zhou, Zhijun
Feng, Suying
Qian, Hua
Hashimoto, Takashi
Li, Xiaoguang
Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies
title Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies
title_full Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies
title_fullStr Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies
title_full_unstemmed Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies
title_short Case report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies
title_sort case report: mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of iga autoantibodies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033602/
https://www.ncbi.nlm.nih.gov/pubmed/36969205
http://dx.doi.org/10.3389/fimmu.2023.1149119
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