Correction of F8 intron 1 inversion in hemophilia A patient-specific iPSCs by CRISPR/Cas9 mediated gene editing

Introduction: Hemophilia A (HA) is the most common genetic bleeding disorder caused by mutations in the F8 gene encoding coagulation factor VIII (FVIII). As the second predominant pathogenic mutation in hemophilia A severe patients, F8 Intron one inversion (Inv1) completely splits the F8 gene into t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Zhiqing, Wu, Yong, Xiao, Rou, Zhao, Junya, Chen, Yan, Wu, Lingqian, Zhou, Miaojin, Liang, Desheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033665/
https://www.ncbi.nlm.nih.gov/pubmed/36968612
http://dx.doi.org/10.3389/fgene.2023.1115831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033665/
https://www.ncbi.nlm.nih.gov/pubmed/36968612
http://dx.doi.org/10.3389/fgene.2023.1115831

Ejemplares similares