Epigenetic state determines the in vivo efficacy of STING agonist therapy

While STING-activating agents have shown limited efficacy in early-phase clinical trials, multiple lines of evidence suggest the importance of tumor cell-intrinsic STING function in mediating antitumor immune responses. Although STING signaling is impaired in human melanoma, its restoration through...

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Detalles Bibliográficos
Autores principales: Falahat, Rana, Berglund, Anders, Perez-Villarroel, Patricio, Putney, Ryan M., Hamaidi, Imene, Kim, Sungjune, Pilon-Thomas, Shari, Barber, Glen N., Mulé, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033671/
https://www.ncbi.nlm.nih.gov/pubmed/36949064
http://dx.doi.org/10.1038/s41467-023-37217-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033671/
https://www.ncbi.nlm.nih.gov/pubmed/36949064
http://dx.doi.org/10.1038/s41467-023-37217-1

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