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Prenatal environment impacts telomere length in newborn dairy heifers
Telomere length is associated with longevity and survival in multiple species. In human population-based studies, multiple prenatal factors have been described to be associated with a newborn’s telomere length. In the present study, we measured relative leukocyte telomere length in 210 Holstein Frie...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033676/ https://www.ncbi.nlm.nih.gov/pubmed/36949104 http://dx.doi.org/10.1038/s41598-023-31943-8 |
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author | Meesters, Maya Van Eetvelde, Mieke Martens, Dries S. Nawrot, Tim S. Dewulf, Manon Govaere, Jan Opsomer, Geert |
author_facet | Meesters, Maya Van Eetvelde, Mieke Martens, Dries S. Nawrot, Tim S. Dewulf, Manon Govaere, Jan Opsomer, Geert |
author_sort | Meesters, Maya |
collection | PubMed |
description | Telomere length is associated with longevity and survival in multiple species. In human population-based studies, multiple prenatal factors have been described to be associated with a newborn’s telomere length. In the present study, we measured relative leukocyte telomere length in 210 Holstein Friesian heifers, within the first ten days of life. The dam’s age, parity, and milk production parameters, as well as environmental factors during gestation were assessed for their potential effect on telomere length. We found that for both primi- and multiparous dams, the telomere length was 1.16% shorter for each day increase in the calf’s age at sampling (P = 0.017). The dam’s age at parturition (P = 0.045), and the median temperature-humidity index (THI) during the third trimester of gestation (P = 0.006) were also negatively associated with the calves’ TL. Investigating multiparous dams separately, only the calf’s age at sampling was significantly and negatively associated with the calves’ TL (P = 0.025). Results of the present study support the hypothesis that in cattle, early life telomere length is influenced by prenatal factors. Furthermore, the results suggest that selecting heifers born in winter out of young dams might contribute to increased longevity in dairy cattle. |
format | Online Article Text |
id | pubmed-10033676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100336762023-03-24 Prenatal environment impacts telomere length in newborn dairy heifers Meesters, Maya Van Eetvelde, Mieke Martens, Dries S. Nawrot, Tim S. Dewulf, Manon Govaere, Jan Opsomer, Geert Sci Rep Article Telomere length is associated with longevity and survival in multiple species. In human population-based studies, multiple prenatal factors have been described to be associated with a newborn’s telomere length. In the present study, we measured relative leukocyte telomere length in 210 Holstein Friesian heifers, within the first ten days of life. The dam’s age, parity, and milk production parameters, as well as environmental factors during gestation were assessed for their potential effect on telomere length. We found that for both primi- and multiparous dams, the telomere length was 1.16% shorter for each day increase in the calf’s age at sampling (P = 0.017). The dam’s age at parturition (P = 0.045), and the median temperature-humidity index (THI) during the third trimester of gestation (P = 0.006) were also negatively associated with the calves’ TL. Investigating multiparous dams separately, only the calf’s age at sampling was significantly and negatively associated with the calves’ TL (P = 0.025). Results of the present study support the hypothesis that in cattle, early life telomere length is influenced by prenatal factors. Furthermore, the results suggest that selecting heifers born in winter out of young dams might contribute to increased longevity in dairy cattle. Nature Publishing Group UK 2023-03-22 /pmc/articles/PMC10033676/ /pubmed/36949104 http://dx.doi.org/10.1038/s41598-023-31943-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Meesters, Maya Van Eetvelde, Mieke Martens, Dries S. Nawrot, Tim S. Dewulf, Manon Govaere, Jan Opsomer, Geert Prenatal environment impacts telomere length in newborn dairy heifers |
title | Prenatal environment impacts telomere length in newborn dairy heifers |
title_full | Prenatal environment impacts telomere length in newborn dairy heifers |
title_fullStr | Prenatal environment impacts telomere length in newborn dairy heifers |
title_full_unstemmed | Prenatal environment impacts telomere length in newborn dairy heifers |
title_short | Prenatal environment impacts telomere length in newborn dairy heifers |
title_sort | prenatal environment impacts telomere length in newborn dairy heifers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033676/ https://www.ncbi.nlm.nih.gov/pubmed/36949104 http://dx.doi.org/10.1038/s41598-023-31943-8 |
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