Cargando…
Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs
In this study, we assessed the efficacy of a novel Bacillus subtilis probiotic in improving growth performance and gut responses in comparison to pharmacological zinc oxide (ZnO) in nursery pigs. A total of 96 piglets were randomly assigned to four groups: Negative control (NC), Positive control (PC...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033705/ https://www.ncbi.nlm.nih.gov/pubmed/36949225 http://dx.doi.org/10.1038/s41598-023-31913-0 |
_version_ | 1784911051741986816 |
---|---|
author | Sudan, Sudhanshu Fletcher, Lauren Zhan, Xiaoshu Dingle, Serena Patterson, Rob Huber, Lee-Anne Friendship, Robert Kiarie, Elijah G. Li, Julang |
author_facet | Sudan, Sudhanshu Fletcher, Lauren Zhan, Xiaoshu Dingle, Serena Patterson, Rob Huber, Lee-Anne Friendship, Robert Kiarie, Elijah G. Li, Julang |
author_sort | Sudan, Sudhanshu |
collection | PubMed |
description | In this study, we assessed the efficacy of a novel Bacillus subtilis probiotic in improving growth performance and gut responses in comparison to pharmacological zinc oxide (ZnO) in nursery pigs. A total of 96 piglets were randomly assigned to four groups: Negative control (NC), Positive control (PC, 3000 mg Zn /kg feed), B.subtilis low dose (BS9-L, 2 × 10(7) CFU/pig) and B.subtilis high dose (BS9-H, 2 × 10(9) CFU/pig). Growth performance, diarrhea rate, gut mucosal gene expression and fecal microbial populations were evaluated. B.subtilis administration did not improve piglet bodyweight. BS9-L showed (P < 0.05) higher average daily gain (ADG) in Period 2 (D14-D28). BS9 groups had (P < 0.001) lower feed conversion ratio (FCR) in Period 2 (D14-D28) and overall. Like the ZnO-group, BS9 groups had lower (P < 0.01) diarrhea rate. A significant reduction (P < 0.05) in fecal E. coli, total coliforms, and an increase in lactic acid bacteria and Bacillus spp. in BS9 groups was observed. BS9 group had reduced (P < 0.05) mRNA levels of intestinal IL-8 and higher levels of MUC-1 and occludin and TJP-1 compared to negative control. These findings suggest that probiotic BS9, may promote growth performance, and ameliorate various indicators of intestinal health in piglets. Hence, it may serve as a prospective alternative to ZnO growth promoter in commercial swine production. |
format | Online Article Text |
id | pubmed-10033705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100337052023-03-24 Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs Sudan, Sudhanshu Fletcher, Lauren Zhan, Xiaoshu Dingle, Serena Patterson, Rob Huber, Lee-Anne Friendship, Robert Kiarie, Elijah G. Li, Julang Sci Rep Article In this study, we assessed the efficacy of a novel Bacillus subtilis probiotic in improving growth performance and gut responses in comparison to pharmacological zinc oxide (ZnO) in nursery pigs. A total of 96 piglets were randomly assigned to four groups: Negative control (NC), Positive control (PC, 3000 mg Zn /kg feed), B.subtilis low dose (BS9-L, 2 × 10(7) CFU/pig) and B.subtilis high dose (BS9-H, 2 × 10(9) CFU/pig). Growth performance, diarrhea rate, gut mucosal gene expression and fecal microbial populations were evaluated. B.subtilis administration did not improve piglet bodyweight. BS9-L showed (P < 0.05) higher average daily gain (ADG) in Period 2 (D14-D28). BS9 groups had (P < 0.001) lower feed conversion ratio (FCR) in Period 2 (D14-D28) and overall. Like the ZnO-group, BS9 groups had lower (P < 0.01) diarrhea rate. A significant reduction (P < 0.05) in fecal E. coli, total coliforms, and an increase in lactic acid bacteria and Bacillus spp. in BS9 groups was observed. BS9 group had reduced (P < 0.05) mRNA levels of intestinal IL-8 and higher levels of MUC-1 and occludin and TJP-1 compared to negative control. These findings suggest that probiotic BS9, may promote growth performance, and ameliorate various indicators of intestinal health in piglets. Hence, it may serve as a prospective alternative to ZnO growth promoter in commercial swine production. Nature Publishing Group UK 2023-03-22 /pmc/articles/PMC10033705/ /pubmed/36949225 http://dx.doi.org/10.1038/s41598-023-31913-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sudan, Sudhanshu Fletcher, Lauren Zhan, Xiaoshu Dingle, Serena Patterson, Rob Huber, Lee-Anne Friendship, Robert Kiarie, Elijah G. Li, Julang Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
title | Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
title_full | Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
title_fullStr | Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
title_full_unstemmed | Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
title_short | Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
title_sort | comparative efficacy of a novel bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033705/ https://www.ncbi.nlm.nih.gov/pubmed/36949225 http://dx.doi.org/10.1038/s41598-023-31913-0 |
work_keys_str_mv | AT sudansudhanshu comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT fletcherlauren comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT zhanxiaoshu comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT dingleserena comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT pattersonrob comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT huberleeanne comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT friendshiprobert comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT kiarieelijahg comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs AT lijulang comparativeefficacyofanovelbacillussubtilisbasedprobioticandpharmacologicalzincoxideongrowthperformanceandgutresponsesinnurserypigs |