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New AAV tools fail to detect Neurod1-mediated neuronal conversion of Müller glia and astrocytes in vivo

BACKGROUND: Reprogramming resident glial cells to convert them into neurons in vivo represents a potential therapeutic strategy that could replenish lost neurons, repair damaged neural circuits, and restore function. AAV (adeno-associated virus)-based expression systems are powerful tools for in viv...

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Detalles Bibliográficos
Autores principales: Xie, Ye, Zhou, Jing, Wang, Lei-Lei, Zhang, Chun-Li, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033723/
https://www.ncbi.nlm.nih.gov/pubmed/36947961
http://dx.doi.org/10.1016/j.ebiom.2023.104531