Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD

Transactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the brains, spinal cord, and lower motor neurons of affe...

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Detalles Bibliográficos
Autores principales: Yusuff, Tanzeen, Chang, Ya-Chu, Sang, Tzu-Kang, Jackson, George R., Chatterjee, Shreyasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034021/
https://www.ncbi.nlm.nih.gov/pubmed/36968586
http://dx.doi.org/10.3389/fgene.2023.881638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034021/
https://www.ncbi.nlm.nih.gov/pubmed/36968586
http://dx.doi.org/10.3389/fgene.2023.881638

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