Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes

OBJECTIVE: The pro-inflammatory cytokine interleukin-1β (IL-1β) plays a central role in host defense against infections. High systemic IL-1β levels, however, promote the pathogenesis of inflammatory disorders. Therefore, mechanisms controlling IL-1β release are of substantial clinical interest. Rece...

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Detalles Bibliográficos
Autores principales: Richter, Katrin, Asci, Nilay, Singh, Vijay K., Yakoob, Sanaria Hawro, Meixner, Marion, Zakrzewicz, Anna, Liese, Juliane, Hecker, Andreas, Wilker, Sigrid, Stumpf, Sabine, Schlüter, Klaus-Dieter, Rohde, Marius, Gödecke, Axel, Padberg, Winfried, Manzini, Ivan, Schmalzing, Günther, Grau, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034071/
https://www.ncbi.nlm.nih.gov/pubmed/36969210
http://dx.doi.org/10.3389/fimmu.2023.1140592

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