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Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis

Although psoriasis is classified as a T cell-mediated inflammatory disease, the contribution of myeloid cells to the pathogenesis of psoriasis is not fully understood. In the present study, we demonstrated that the expression of the anti-inflammatory cytokine interleukin-35 (IL-35) was significantly...

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Autores principales: Zhang, Junfeng, Zhang, Yunsheng, Yang, Zhiya, Cheng, Dalei, Zhang, Hui, Wei, Li, Liu, Chen, Yan, Fenglian, Li, Chunxia, Dong, Guanjun, Wang, Changying, Shi, Dongmei, Xiong, Huabao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034090/
https://www.ncbi.nlm.nih.gov/pubmed/36969174
http://dx.doi.org/10.3389/fimmu.2023.1091541
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author Zhang, Junfeng
Zhang, Yunsheng
Yang, Zhiya
Cheng, Dalei
Zhang, Hui
Wei, Li
Liu, Chen
Yan, Fenglian
Li, Chunxia
Dong, Guanjun
Wang, Changying
Shi, Dongmei
Xiong, Huabao
author_facet Zhang, Junfeng
Zhang, Yunsheng
Yang, Zhiya
Cheng, Dalei
Zhang, Hui
Wei, Li
Liu, Chen
Yan, Fenglian
Li, Chunxia
Dong, Guanjun
Wang, Changying
Shi, Dongmei
Xiong, Huabao
author_sort Zhang, Junfeng
collection PubMed
description Although psoriasis is classified as a T cell-mediated inflammatory disease, the contribution of myeloid cells to the pathogenesis of psoriasis is not fully understood. In the present study, we demonstrated that the expression of the anti-inflammatory cytokine interleukin-35 (IL-35) was significantly increased in patients with psoriasis with a marked increase in the number of myeloid-derived suppressor cells (MDSCs). Similar results were obtained in an imiquimod-induced psoriasis mouse model. IL-35 reduced the total number of MDSCs and their subtypes in the spleens and psoriatic skin lesions, ameliorating psoriasis. IL-35 also reduced the expression of inducible nitric oxide synthase in MDSCs, although it had no significant effect on interleukin-10 expression. Adoptive transfer of MDSCs from imiquimod-challenged mice aggravated the disease and weakened the effect of IL-35 in the recipient mice. In addition, mice transferred with MDSCs isolated from inducible nitric oxide synthase knockout mice had milder disease than those with wild-type MDSCs. Furthermore, wild-type MDSCs reversed the effects of IL-35, while MDSCs isolated from inducible nitric oxide synthase knockout mice did not affect IL-35 treatment. In summary, IL-35 may play a critical role in the regulation of iNOS-expressing MDSCs in the pathogenesis of psoriasis, highlighting IL-35 as a novel therapeutic strategy for patients with chronic psoriasis or other cutaneous inflammatory diseases.
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spelling pubmed-100340902023-03-24 Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis Zhang, Junfeng Zhang, Yunsheng Yang, Zhiya Cheng, Dalei Zhang, Hui Wei, Li Liu, Chen Yan, Fenglian Li, Chunxia Dong, Guanjun Wang, Changying Shi, Dongmei Xiong, Huabao Front Immunol Immunology Although psoriasis is classified as a T cell-mediated inflammatory disease, the contribution of myeloid cells to the pathogenesis of psoriasis is not fully understood. In the present study, we demonstrated that the expression of the anti-inflammatory cytokine interleukin-35 (IL-35) was significantly increased in patients with psoriasis with a marked increase in the number of myeloid-derived suppressor cells (MDSCs). Similar results were obtained in an imiquimod-induced psoriasis mouse model. IL-35 reduced the total number of MDSCs and their subtypes in the spleens and psoriatic skin lesions, ameliorating psoriasis. IL-35 also reduced the expression of inducible nitric oxide synthase in MDSCs, although it had no significant effect on interleukin-10 expression. Adoptive transfer of MDSCs from imiquimod-challenged mice aggravated the disease and weakened the effect of IL-35 in the recipient mice. In addition, mice transferred with MDSCs isolated from inducible nitric oxide synthase knockout mice had milder disease than those with wild-type MDSCs. Furthermore, wild-type MDSCs reversed the effects of IL-35, while MDSCs isolated from inducible nitric oxide synthase knockout mice did not affect IL-35 treatment. In summary, IL-35 may play a critical role in the regulation of iNOS-expressing MDSCs in the pathogenesis of psoriasis, highlighting IL-35 as a novel therapeutic strategy for patients with chronic psoriasis or other cutaneous inflammatory diseases. Frontiers Media S.A. 2023-03-09 /pmc/articles/PMC10034090/ /pubmed/36969174 http://dx.doi.org/10.3389/fimmu.2023.1091541 Text en Copyright © 2023 Zhang, Zhang, Yang, Cheng, Zhang, Wei, Liu, Yan, Li, Dong, Wang, Shi and Xiong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Junfeng
Zhang, Yunsheng
Yang, Zhiya
Cheng, Dalei
Zhang, Hui
Wei, Li
Liu, Chen
Yan, Fenglian
Li, Chunxia
Dong, Guanjun
Wang, Changying
Shi, Dongmei
Xiong, Huabao
Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
title Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
title_full Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
title_fullStr Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
title_full_unstemmed Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
title_short Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
title_sort inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034090/
https://www.ncbi.nlm.nih.gov/pubmed/36969174
http://dx.doi.org/10.3389/fimmu.2023.1091541
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