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Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers
The objective of this study was to explore the impact of maternal AT during pregnancy on childhood asthma and wheezing, as well as the potential effect modifiers in this association. A cross-sectional study was implemented from December 2018 to March 2019 in Jinan to investigate the prevalence of ch...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034250/ https://www.ncbi.nlm.nih.gov/pubmed/36952159 http://dx.doi.org/10.1007/s11356-023-26234-8 |
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author | Zhang, Jiatao Bai, Shuoxin Lin, Shaoqian Cui, Liangliang Zhao, Xiaodong Du, Shuang Wang, Zhiping |
author_facet | Zhang, Jiatao Bai, Shuoxin Lin, Shaoqian Cui, Liangliang Zhao, Xiaodong Du, Shuang Wang, Zhiping |
author_sort | Zhang, Jiatao |
collection | PubMed |
description | The objective of this study was to explore the impact of maternal AT during pregnancy on childhood asthma and wheezing, as well as the potential effect modifiers in this association. A cross-sectional study was implemented from December 2018 to March 2019 in Jinan to investigate the prevalence of childhood asthma and wheezing among aged 18 months to 3 years. Then, we conducted a case-control study based on population to explore the association between prenatal different AT exposure levels and childhood asthma and wheezing. The association was assessed by generalized additive models and logistic regression models, and stratified analyses were performed to explore potential effect modifiers. A total of 12,384 vaccinated children participated in screening for asthma and wheezing, 236 cases were screened, as well as 1445 controls were randomized. After adjusting for the covariates, childhood asthma and wheezing were significantly associated with cold exposure in the first trimester, with OR 1.731 (95% CI: 1.117–2.628), and cold exposure and heat exposure in the third trimester, with ORs 1.610 (95% CI: 1.030–2.473) and 2.039 (95% CI: 1.343–3.048). In the third trimester, enhanced impacts were found among girls, children whose distance of residence was close to the nearest main traffic road, and children whose parents have asthma. The study indicates that exposure to extreme AT during the first and third trimesters could increase the risk of childhood asthma and wheezing. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-023-26234-8. |
format | Online Article Text |
id | pubmed-10034250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-100342502023-03-23 Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers Zhang, Jiatao Bai, Shuoxin Lin, Shaoqian Cui, Liangliang Zhao, Xiaodong Du, Shuang Wang, Zhiping Environ Sci Pollut Res Int Research Article The objective of this study was to explore the impact of maternal AT during pregnancy on childhood asthma and wheezing, as well as the potential effect modifiers in this association. A cross-sectional study was implemented from December 2018 to March 2019 in Jinan to investigate the prevalence of childhood asthma and wheezing among aged 18 months to 3 years. Then, we conducted a case-control study based on population to explore the association between prenatal different AT exposure levels and childhood asthma and wheezing. The association was assessed by generalized additive models and logistic regression models, and stratified analyses were performed to explore potential effect modifiers. A total of 12,384 vaccinated children participated in screening for asthma and wheezing, 236 cases were screened, as well as 1445 controls were randomized. After adjusting for the covariates, childhood asthma and wheezing were significantly associated with cold exposure in the first trimester, with OR 1.731 (95% CI: 1.117–2.628), and cold exposure and heat exposure in the third trimester, with ORs 1.610 (95% CI: 1.030–2.473) and 2.039 (95% CI: 1.343–3.048). In the third trimester, enhanced impacts were found among girls, children whose distance of residence was close to the nearest main traffic road, and children whose parents have asthma. The study indicates that exposure to extreme AT during the first and third trimesters could increase the risk of childhood asthma and wheezing. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-023-26234-8. Springer Berlin Heidelberg 2023-03-23 2023 /pmc/articles/PMC10034250/ /pubmed/36952159 http://dx.doi.org/10.1007/s11356-023-26234-8 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Research Article Zhang, Jiatao Bai, Shuoxin Lin, Shaoqian Cui, Liangliang Zhao, Xiaodong Du, Shuang Wang, Zhiping Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
title | Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
title_full | Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
title_fullStr | Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
title_full_unstemmed | Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
title_short | Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
title_sort | maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034250/ https://www.ncbi.nlm.nih.gov/pubmed/36952159 http://dx.doi.org/10.1007/s11356-023-26234-8 |
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