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Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review

Basal cell carcinoma of the prostate (BCCP) is a rare tumor with a total incidence of 140 cases to date. However, BCCP with squamous metaplasia has not been reported as of date. In this paper, we report the first case of BCCP with squamous metaplasia. The patient was hospitalized for progressive dys...

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Autores principales: Wang, Junwei, Zhang, Cunming, Chen, Baijun, Wu, Qingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034339/
https://www.ncbi.nlm.nih.gov/pubmed/36969067
http://dx.doi.org/10.3389/fonc.2023.1094943
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author Wang, Junwei
Zhang, Cunming
Chen, Baijun
Wu, Qingqing
author_facet Wang, Junwei
Zhang, Cunming
Chen, Baijun
Wu, Qingqing
author_sort Wang, Junwei
collection PubMed
description Basal cell carcinoma of the prostate (BCCP) is a rare tumor with a total incidence of 140 cases to date. However, BCCP with squamous metaplasia has not been reported as of date. In this paper, we report the first case of BCCP with squamous metaplasia. The patient was hospitalized for progressive dyspareunia and had been treated for recurrent urinary retention four times in 5 years. Rectal examination showed that the prostate was medium in texture with no palpable nodules. The levels of total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), and fPSA/tPSA (f/t) ratio were 1.29 ng/mL, 0.4 ng/mL, and 0.31, respectively. Ultrasound of the urinary tract showed that the prostate gland was 51 mm*40 mm*38 mm in size. We performed transurethral resection of the prostate. Histopathology confirmed the diagnosis of basal cell carcinoma with focal squamous differentiation, and immunohistochemical staining was positive for P63 and 34βE12. A laparoscopic radical prostatectomy was performed 45 days after the first surgery and the postoperative pathology showed a small amount of residual tumor with negative margins and no involvement of the seminal vesicles and vas deferens. The patient was followed up for 50 months and was doing well by the end of our study. We describe the clinical symptoms, pathological features, treatment, and prognosis of patients with BCCP with squamous metaplasia. The relevant published literature is also briefly reviewed.
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spelling pubmed-100343392023-03-24 Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review Wang, Junwei Zhang, Cunming Chen, Baijun Wu, Qingqing Front Oncol Oncology Basal cell carcinoma of the prostate (BCCP) is a rare tumor with a total incidence of 140 cases to date. However, BCCP with squamous metaplasia has not been reported as of date. In this paper, we report the first case of BCCP with squamous metaplasia. The patient was hospitalized for progressive dyspareunia and had been treated for recurrent urinary retention four times in 5 years. Rectal examination showed that the prostate was medium in texture with no palpable nodules. The levels of total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), and fPSA/tPSA (f/t) ratio were 1.29 ng/mL, 0.4 ng/mL, and 0.31, respectively. Ultrasound of the urinary tract showed that the prostate gland was 51 mm*40 mm*38 mm in size. We performed transurethral resection of the prostate. Histopathology confirmed the diagnosis of basal cell carcinoma with focal squamous differentiation, and immunohistochemical staining was positive for P63 and 34βE12. A laparoscopic radical prostatectomy was performed 45 days after the first surgery and the postoperative pathology showed a small amount of residual tumor with negative margins and no involvement of the seminal vesicles and vas deferens. The patient was followed up for 50 months and was doing well by the end of our study. We describe the clinical symptoms, pathological features, treatment, and prognosis of patients with BCCP with squamous metaplasia. The relevant published literature is also briefly reviewed. Frontiers Media S.A. 2023-03-09 /pmc/articles/PMC10034339/ /pubmed/36969067 http://dx.doi.org/10.3389/fonc.2023.1094943 Text en Copyright © 2023 Wang, Zhang, Chen and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Junwei
Zhang, Cunming
Chen, Baijun
Wu, Qingqing
Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review
title Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review
title_full Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review
title_fullStr Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review
title_full_unstemmed Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review
title_short Basal cell carcinoma of the prostate with squamous metaplasia: A case report and literature review
title_sort basal cell carcinoma of the prostate with squamous metaplasia: a case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034339/
https://www.ncbi.nlm.nih.gov/pubmed/36969067
http://dx.doi.org/10.3389/fonc.2023.1094943
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