Peripheral blood mononuclear cells reactivity in recent-onset type I diabetes patients is directed against the leader peptide of preproinsulin, GAD65(271-285) and GAD65(431-450)

INTRODUCTION: T cell reactivity against pancreatic autoantigens is considered one of the main contributors to the destruction of insulin-producing cells in type 1 diabetes (T1D). Over the years, peptide epitopes derived from these autoantigens have been described in NOD mice and in both HLA class II...

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Detalles Bibliográficos
Autores principales: Jores, Rita D., Baldera, Davide, Schirru, Enrico, Muntoni, Sandro, Rossino, Rossano, Manchinu, Maria F., Marongiu, Maria F., Caria, Cristian A., Ripoli, Carlo, Ricciardi, Maria R., Cucca, Francesco, Congia, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034372/
https://www.ncbi.nlm.nih.gov/pubmed/36969220
http://dx.doi.org/10.3389/fimmu.2023.1130019

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