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Biosynthesis of anticancer phytochemical compounds and their chemistry

Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tu...

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Autores principales: Dogra, Amandeep, Kumar, Jitender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034375/
https://www.ncbi.nlm.nih.gov/pubmed/36969868
http://dx.doi.org/10.3389/fphar.2023.1136779
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author Dogra, Amandeep
Kumar, Jitender
author_facet Dogra, Amandeep
Kumar, Jitender
author_sort Dogra, Amandeep
collection PubMed
description Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption remain more significant obstacles in clinical trials. Therefore, drug combinations of new phytochemical compounds, phytonanomedicine, semi-synthetic, and synthetic analogs should be considered to supplement the existing cancer therapies. It is also crucial to consider different strategies for increased production of phytochemical bioactive substances. The primary goal of this review is to highlight several bioactive anticancer phytochemical compounds found in plants, preclinical research, their synthetic and semi-synthetic analogs, and clinical trials. Additionally, biotechnological and metabolic engineering strategies are explored to enhance the production of bioactive phytochemical compounds. Ligands and their interactions with their putative targets are also explored through molecular docking studies. Therefore, emphasis is given to gathering comprehensive data regarding modern biotechnology, metabolic engineering, molecular biology, and in silico tools.
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spelling pubmed-100343752023-03-24 Biosynthesis of anticancer phytochemical compounds and their chemistry Dogra, Amandeep Kumar, Jitender Front Pharmacol Pharmacology Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption remain more significant obstacles in clinical trials. Therefore, drug combinations of new phytochemical compounds, phytonanomedicine, semi-synthetic, and synthetic analogs should be considered to supplement the existing cancer therapies. It is also crucial to consider different strategies for increased production of phytochemical bioactive substances. The primary goal of this review is to highlight several bioactive anticancer phytochemical compounds found in plants, preclinical research, their synthetic and semi-synthetic analogs, and clinical trials. Additionally, biotechnological and metabolic engineering strategies are explored to enhance the production of bioactive phytochemical compounds. Ligands and their interactions with their putative targets are also explored through molecular docking studies. Therefore, emphasis is given to gathering comprehensive data regarding modern biotechnology, metabolic engineering, molecular biology, and in silico tools. Frontiers Media S.A. 2023-03-09 /pmc/articles/PMC10034375/ /pubmed/36969868 http://dx.doi.org/10.3389/fphar.2023.1136779 Text en Copyright © 2023 Dogra and Kumar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Dogra, Amandeep
Kumar, Jitender
Biosynthesis of anticancer phytochemical compounds and their chemistry
title Biosynthesis of anticancer phytochemical compounds and their chemistry
title_full Biosynthesis of anticancer phytochemical compounds and their chemistry
title_fullStr Biosynthesis of anticancer phytochemical compounds and their chemistry
title_full_unstemmed Biosynthesis of anticancer phytochemical compounds and their chemistry
title_short Biosynthesis of anticancer phytochemical compounds and their chemistry
title_sort biosynthesis of anticancer phytochemical compounds and their chemistry
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034375/
https://www.ncbi.nlm.nih.gov/pubmed/36969868
http://dx.doi.org/10.3389/fphar.2023.1136779
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