Case report: A de novo ERBB3 mutation develops in a gallbladder cancer patient carrying BRCA1 mutation after effective treatment with olaparib

BACKGROUND: Gallbladder cancer (GBC) is highly lethal and resistant to most chemotherapeutic drugs. GBC was reported to carry multiple genetic mutations such as TP53, K-RAS, and ERBB2/3. Here, we unexpectedly identified a patient with GBC harboring germline BRCA1 p.Arg1325Lys heterozygous mutation....

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Detalles Bibliográficos
Autores principales: Yang, Jing-Xiao, Jia, Zi-Yao, Liu, Fa-Tao, Wu, Wen-Guang, Li, Xue-Chuan, Zou, Lu, Li, Huai-Feng, Zhang, Fei, Bao, Run-Fa, Peng, Shu-You, Lau, Wan Yee, Liu, Yun, Li, Mao-Lan, Liu, Ying-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034383/
https://www.ncbi.nlm.nih.gov/pubmed/36969051
http://dx.doi.org/10.3389/fonc.2023.1078388

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