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The link between immunity and hypertension in the kidney and heart
Hypertension is the primary cause of cardiovascular disease, which is a leading killer worldwide. Despite the prevalence of this non-communicable disease, still between 90% and 95% of cases are of unknown or multivariate cause (“essential hypertension”). Current therapeutic options focus primarily o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034415/ https://www.ncbi.nlm.nih.gov/pubmed/36970367 http://dx.doi.org/10.3389/fcvm.2023.1129384 |
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author | Benson, Lance N. Guo, Yunping Deck, Katherine Mora, Christoph Liu, Yunmeng Mu, Shengyu |
author_facet | Benson, Lance N. Guo, Yunping Deck, Katherine Mora, Christoph Liu, Yunmeng Mu, Shengyu |
author_sort | Benson, Lance N. |
collection | PubMed |
description | Hypertension is the primary cause of cardiovascular disease, which is a leading killer worldwide. Despite the prevalence of this non-communicable disease, still between 90% and 95% of cases are of unknown or multivariate cause (“essential hypertension”). Current therapeutic options focus primarily on lowering blood pressure through decreasing peripheral resistance or reducing fluid volume, but fewer than half of hypertensive patients can reach blood pressure control. Hence, identifying unknown mechanisms causing essential hypertension and designing new treatment accordingly are critically needed for improving public health. In recent years, the immune system has been increasingly implicated in contributing to a plethora of cardiovascular diseases. Many studies have demonstrated the critical role of the immune system in the pathogenesis of hypertension, particularly through pro-inflammatory mechanisms within the kidney and heart, which, eventually, drive a myriad of renal and cardiovascular diseases. However, the precise mechanisms and potential therapeutic targets remain largely unknown. Therefore, identifying which immune players are contributing to local inflammation and characterizing pro-inflammatory molecules and mechanisms involved will provide promising new therapeutic targets that could lower blood pressure and prevent progression from hypertension into renal or cardiac dysfunction. |
format | Online Article Text |
id | pubmed-10034415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100344152023-03-24 The link between immunity and hypertension in the kidney and heart Benson, Lance N. Guo, Yunping Deck, Katherine Mora, Christoph Liu, Yunmeng Mu, Shengyu Front Cardiovasc Med Cardiovascular Medicine Hypertension is the primary cause of cardiovascular disease, which is a leading killer worldwide. Despite the prevalence of this non-communicable disease, still between 90% and 95% of cases are of unknown or multivariate cause (“essential hypertension”). Current therapeutic options focus primarily on lowering blood pressure through decreasing peripheral resistance or reducing fluid volume, but fewer than half of hypertensive patients can reach blood pressure control. Hence, identifying unknown mechanisms causing essential hypertension and designing new treatment accordingly are critically needed for improving public health. In recent years, the immune system has been increasingly implicated in contributing to a plethora of cardiovascular diseases. Many studies have demonstrated the critical role of the immune system in the pathogenesis of hypertension, particularly through pro-inflammatory mechanisms within the kidney and heart, which, eventually, drive a myriad of renal and cardiovascular diseases. However, the precise mechanisms and potential therapeutic targets remain largely unknown. Therefore, identifying which immune players are contributing to local inflammation and characterizing pro-inflammatory molecules and mechanisms involved will provide promising new therapeutic targets that could lower blood pressure and prevent progression from hypertension into renal or cardiac dysfunction. Frontiers Media S.A. 2023-03-09 /pmc/articles/PMC10034415/ /pubmed/36970367 http://dx.doi.org/10.3389/fcvm.2023.1129384 Text en © 2023 Benson, Guo, Deck, Mora, Liu and Mu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Benson, Lance N. Guo, Yunping Deck, Katherine Mora, Christoph Liu, Yunmeng Mu, Shengyu The link between immunity and hypertension in the kidney and heart |
title | The link between immunity and hypertension in the kidney and heart |
title_full | The link between immunity and hypertension in the kidney and heart |
title_fullStr | The link between immunity and hypertension in the kidney and heart |
title_full_unstemmed | The link between immunity and hypertension in the kidney and heart |
title_short | The link between immunity and hypertension in the kidney and heart |
title_sort | link between immunity and hypertension in the kidney and heart |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034415/ https://www.ncbi.nlm.nih.gov/pubmed/36970367 http://dx.doi.org/10.3389/fcvm.2023.1129384 |
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